MCAT Biology : Reactions with Nitrogen Compounds

Study concepts, example questions & explanations for MCAT Biology

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Example Questions

Example Question #1 : Reactions

Which of the following statements is true concerning the Hofmann elimination reaction?

Possible Answers:

The quaternary ammonium salt is a poor leaving group

The ammonium is eliminated following an E1 mechanism

The Zaitsev product is favored in the elimination reaction

The least substituted alkene is the major product in the reaction

Correct answer:

The least substituted alkene is the major product in the reaction

Explanation:

The Hofmann product is the most favored product in a Hofmann elimination reaction. The reaction follows an E2 mechanism, where a quaternary ammonium salt is able to be removed from a hydrocarbon, resulting in an alkene product. This reaction results in the least substituted alkene being the primary product.

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