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Example Questions
Example Question #441 : Systems Physiology
A patient has AB positive blood. Which of the following blood types, if transfused, would cause agglutination?
None of these
A positive
B negative
AB negative
O negative
None of these
An AB positive patient is known as a universal recipient because they can receive blood from any blood type. The recipient's antibodies are what will attack foreign antigens. Type AB positive patients produce no antibodies, because any antibody produced would attack their own antigens, causing agglutination. Because type AB patients patients do not produce antibodies, they cannot attack any antigens and they can receive any blood type.
Example Question #442 : Systems Physiology
Which of the following is a key difference between the innate and the adaptive immune systems?
The innate immune system can fight cancers and autoimmune reactions, while the adaptive immune system can only fight bacteria
The adaptive immune system fights antigens at a more efficient rate during subsequent exposures after the first
The adaptive immune system utilizes T-cells, whereas the innate immune system utilizes B-cells
The innate immune system cannot attack antigens that it does not recognize
The adaptive immune system fights bacteria, while the innate immune system fights viruses
The adaptive immune system fights antigens at a more efficient rate during subsequent exposures after the first
The two types of immune reactions found in the human body are the innate and adaptive immune systems. The innate immune system is the first defense for common antigens that enter the body, and will respond to any and all foreign antigens that it detects. The adaptive immune system utilizes antibodies to fight antigens that reappear in the body during subsequent exposures, and allows the system to more uniquely attack the specific antigen. Both systems can respond to a variety of different pathogens, including bacteria and viruses.
Example Question #443 : Systems Physiology
Which of the following organs is not involved in the immune response?
Spleen
Lymph nodes
Bone marrow
Thymus
Heart
Heart
The heart is the only organ listed that is not involved in the immune response. The thymus is the site of T-cell maturation, while bone marrow is the site of B-cell maturation. The lymph nodes and spleen are sites of blood filtration to ensure that there are no pathogens in the system.
Example Question #444 : Systems Physiology
Which of the following is not a characteristic of the adaptive immune system?
Memory component
General response to an invasion
Produces antibodies
Takes a week or two to develop
Differentiates between foreign and self cells
General response to an invasion
The innate immune system is the general, non-specific response to pathogens. It does not involve a memory component. The adaptive immune system is the more complex, specific response to pathogens. The adaptive immune system takes longer to develop, is able to discriminate between self cells and non self cells, and has a memory component so the second reaction is a quicker response to infection.
Example Question #445 : Systems Physiology
Where does the processing and maturation of T-lymphocytes occur?
Blood
Bone marrow
Spleen
Thyroid
Thymus
Thymus
The thymus is one of two primary lymphoid tissues and is the site of T cell processing, and maturation. These cells are sometimes referred to as thymocytes. The bone marrow is the other primary lymphoid tissue and is the site of B cell maturation.
Example Question #446 : Systems Physiology
Which is an organ of the immune system?
Spleen
Stomach
Heart
Liver
Gallbladder
Spleen
Tissues of the immune system are classified as central (primary) or peripheral (secondary). Peripheral tissues initiate adaptive immune responses. Peripheral lymphoid organs include: lymph nodes, spleen, and the mucosal and cutaneous immune systems (ex: peyers patches in the gastrointestinal tract).
Example Question #447 : Systems Physiology
What is the purpose of basophils?
They cause inflammation in order to allow more leukocytes to migrate to the affected area
They engulf bacteria and pathogens in the body
They aid in destroying parasites and addressing allergic reactions
They release antibodies for one specific antigen
They cause inflammation in order to allow more leukocytes to migrate to the affected area
Basophils are part of the innate immunity, and are a key player for stimulating inflammation. Basophils release histamine, which dilates blood vessels and increases the permeability of capillaries. This allows an infection to be walled off in the affected area and helps other white blood cells migrate to the area.
Eosinphils are involved in parasitic immunity and allergic reactions. Neutrophils, macrophages, and monocytes are responsible for phagocytosing foreign pathogens. B-lymphocytes release antibodies against a specific antigen.
Example Question #2 : Help With Cells Of Innate Immunity
Which of the following leukocytes is NOT a granulocyte?
Basophil
Lymphocyte
Eosinophil
Neutrophil
Lymphocyte
White blood cells can be classified by whether or not they have granules in their cytoplasm (granulocytes and agranulocytes). There are three types of granulocytes, and all of them end in the suffix "-phil." Neutrophils, basophils, and eosinophils are considered granulocytes. Lymphocytes are agranulocytes, and do not have granules present in their cytoplasm.
Example Question #448 : Systems Physiology
Which white blood cell type will notably increase during allergies and parasitic infections?
Monocytes
Basophils
Lymphocytes
Eosinophils
Neutrophils
Eosinophils
The white blood cells are typically categorized into several major types. Each of these types have specific roles in the body, and their proportions will change during specific body conditions. Basophils are used to dilate blood vessels by releasing histamine and eosinophils become elevated during parasitic infections and allergy season. Neutrophils play an important role in recruiting other immune cells to damaged tissues. Lymphocytes include B-cells and T-cells and are involved in the adaptive immune response. Monocytes are the preliminary cells that differentiate into macrophages, which are involved in non-specific phagocytosis.
Example Question #41 : Immune Physiology
The human immune system is organized along two broad arms: innate immunity and adaptive immunity. The differences between these two approaches to immunity are not always black and white, but can be described in general terms with regard to immunological memory. Adaptive immunity displays this type of memory, and mounts a more intense response to pathogens upon second and subsequent exposures.
Within adaptive immunity, the system is further divided into humoral immunity and cell-mediated immunity. We can say that antibodies are the primary mediators of the former, while CD8 T-cell based cytotoxicity is the mediator of the latter.
CD4 T-cells, unlike their CD8 counterparts, are involved in both the humoral and cell-mediated arms of adaptive immunity. These CD4 cells drive isotype switching, a process that changes the types of antibodies produced after initial exposure to a pathogen to increase their molecular affinity. Additionally, CD4 cells promote the activity of macrophages to directly digest invading pathogens.
Polymorphonuclear cells are the first cells that typically migrate to the site of infection. They are central in phagocytosing invading pathogens. Once ingested, pathogens are killed via the generation of hyper-reactive oxygen radicals. Which of the following is most likely to mediate the first step in radical oxidation in these cells?
NADPH oxidase
Peroxidase
Superoxide dismutase
Catalase
Enolase
NADPH oxidase
NADPH oxidase is the first enzyme that can be expected to generate radicals from molecular oxygen. Once the radicals have been generated, they react with another enzyme to generate hydrogen peroxide, a more stable molecule. This generation of a stable intermediate protects the polymorphonuclear cell itself from damage.
The final step mediated by myeloperoxidase generates hypochlorite, or bleach, that ultimately kills the ingested pathogens.