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Example Questions
Example Question #431 : Nclex
The chemotherapeutic agent vinblastine interferes with the assembly of microtubules. This is effective in the treatment of certain cancers due to what cellular effect?
Inhibition of DNA synthesis
Destabilization of cellular membranes
Disruption of the formation of mitotic spindles
Inhibition of mitochondrial function
Disruption of the formation of mitotic spindles
Vinblastine and similar chemotherapeutic agents function by disrupting the formation and stability of microtubules in the cell. Because cell division is dependent on microtubule function, loss of microtubule integrity targets rapidly-reproducing cells such as cancer cells.
Example Question #13 : Cell Biology
A solution is said to be __________ when it contains a lower solute concentration than the cell.
Non-tonic
Hypertonic
Isotonic
Hypotonic
Hypotonic
A hypotonic solution is one that contains solutes at a lower concentration than the cell. A cell, such as a red blood cell, will swell when exposed to a hypotonic solution as water moves into the cell to balance the osmotic gradient.
Example Question #432 : Nclex
Which vitamins are necessary to convert glutamic acid into glutamine?
Biotin and folate
Vitamin C and vitamin B12
Vitamin B3 and vitamin B6
Vitamin E and vitamin D
Vitamin B3 and vitamin B6
Vitamin B3 and vitamin B6 are required to convert glutamic acid into glutamine. Biotin (vitamin B7) plays roles in fat and amino acid metabolism, and though there has been no conclusive evidence of its effect on the growth of hair and nails, it is commonly taken as a supplement for these purposes. Folate (vitamin B9) is required during synthesis of red blood cells, and during DNA replication. Folate cannot be synthesized de novo, and thus must be ingested from the diet. Vitamin C is a powerful antioxidant, and is a cofactor to many biological processes. Cobalmin (vitamin B12) is involved in cell metabolism, particularly in that of fatty acids and amino acids. The source of B12 is from the natural flora of the gut. Vitamin D enhances the absorption of minerals such as calcium, magnesium, and zinc from the gastrointestinal tract. Vitamin E is a fat-soluble antioxidant.
Example Question #2 : Nutrition
What B vitamin deficiency is common in alcoholism?
Biotin
Riboflavin (B2)
Folate
Thiamine (B1)
Thiamine (B1)
Alcoholism is associated with thiamine (vitamin B1) deficiency. This is due to multiple factors: poor nutrition, ethanol's inhibition of thiamin transport in the intestine, and reduced storage of thiamine in the liver due to fatty changes.
Example Question #3 : Nutrition
What essential amino acid is a precursor to nitric oxide?
Methionine
Histidine
L-arginine
Leucine
L-arginine
L-arginine is a precursor for the production of nitric oxide, essential to vasodilation. Other precursors to nitric oxide include NADPH, oxygen, and nitric oxide synthetase (NOS) enzymes. These other amino acids do not have essential roles in the nitric oxide synthesis pathway.
Example Question #433 : Nclex
A physician might recommend decreased fluid intake for which of the following conditions?
Pressure ulcer
Vomiting
Renal disease
Nasogastric tube
Renal disease
A physician is most likely to recommend decreased fluid intake in a patient that has renal disease, particularly if they are in any stage of renal failure. This is because a high fluid intake may put undue strain on the already impaired function of the kidney. Increased fluid intake is generally recommended for all of the other conditions listed.
Example Question #3 : Nutrition
What is the most common cause of copper deficiency in the US?
Soil mineral depletion
Gastric bypass
Wilson's disease
Inadequate dietary intake
Gastric bypass
The most common cause of copper deficiency in the United States is gastric bypass. This is due to malabsorption from food. Copper is fairly ubiquitous in soil and in the average American diet. Wilson's disease is a disorder of excess copper, rather than copper deficiency, resulting in a variety of neurological symptoms.
Example Question #434 : Nclex
Which of the following is a symptom of vitamin K deficiency?
Cartilage calcification
Bone malformation
All of these
Petechiae
All of these
Vitamin K deficiency can cause a variety of issues related to inability to form blood clots such as petechiae, excessive bleeding, bruising, heavy menses. This vitamin is also an important part of bone and cartilage formation, with deficiency resulting in malformation of developing bones and cartilage, or deposition of calcium into cartilage or arterial walls.
Example Question #4 : Nutrition
Which of the following spices was shown in several studies to lower blood sugar in type 2 diabetics by decreasing insulin resistance?
Cumin
Cinnamon
Turmeric
Oregano
Cinnamon
An intake of 1-6 grams of cinnamon has been shown in studies to lower blood sugar in patients with type 2 diabetes by as much as 25%, possibly due to its ability to improve insulin sensitivity.
Example Question #5 : Nutrition
Which of the following is the most common cause of osteomalacia?
Vitamin K deficiency
Vitamin D deficiency
Biotin deficiency
Vitamin E deficiency
Vitamin D deficiency
The mot common cause of osteomalacia (known as rickets in children) in the United States is vitamin D deficiency. This is due to vitamin D's vital role in calcium absorption, homeostasis, and metabolism. Osteomalacia is categorized by the softening of the bones.