The diaphragm is innervated by the phrenic nerve. This nerve exits the spine at C3-C5. In the case of spinal cord trauma, if injury occurs above C3, the diaphragm is no longer able to function on its own and breathing assistance is generally required.

Vital capacity is the maximum volume of air a person can exhale after maximum inhalation. Residual volume is the air that remains in the lung after forced exhalation, while functional residual capacity is the volume of air that remains in the lung after a relaxed exhalation. 

Dead space is the volume of air that remains in the trachea, bronchi, and bronchioles during respiration. It does not enter the alveoli and so does not participate in gas exchange. In the average adult, the amount of air left in the dead space after expiration is . 

Tidal breathing is the term for relaxed inhalation and exhalation (as opposed to maximum inspiration and forced exhalation). The average volume of air breathed into and out of the respiratory system during tidal breathing is . 

There are many factors that can cause bronchioconstriction. Some of them are normal physiological responses, such as parasympathetic input or decreased partial pressure of carbon dioxide in the alveoli. Other causes are pathological, such as allergic bronchioconstriction or asthma triggered by cold air.

There are two types of alveolar cells: type I cells and type II cells. Each cell type has a unique function within the alveolus, and the dysfunction of either cell type results in serious respiratory pathology. Type I cells are simple squamous epithelial cells that account for about 95% of all alveolar cells. They are the primary cells responsible for diffusion of gasses across the respiratory membranes. Type I alveolar cells are responsible for secreting surfactant, which facilitates the diffusion of substances across the epithelium.

The diaphragm is a thin sheet of muscle that separates the thoracic cavity from the abdominal cavity. At rest, it is drawn upward into a dome-like shape under the lungs. When the diaphragm contracts, the dome flattens out, which increases the size of the thoracic cavity. The negative pressure allows the lungs to expand and fill with air, causing an increase in total lung volume (inhalation). 

The only chamber of the upper respiratory tract that is shared by both the respiratory and the digestive systems is the pharynx. The pharynx is the part of the throat that is immediately posterior to the mouth and the nasal cavity, and superior to the trachea, larynx, and esophagus. 

The pharynx is made up of three divisions: the laryngopharynx, the oropharynx, and the nasopharynx. There is no portion of the pharynx called the sinopharynx. 

The frontal sinuses are not present at birth. They begin to develop in the first few years of life, but they are not fully mature until after adolescence. The sphenoid, maxillary, and ethmoid sinuses are present at birth, though they are underdeveloped and similarly do not mature fully till late childhood or adolescence.