MCAT Biology : Macromolecules

Study concepts, example questions & explanations for MCAT Biology

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Example Questions

Example Question #4 : Properties Of Lipids

Sexually transmitted diseases are a common problem among young people in the United States. One of the more common diseases is caused by the bacterium Neisseria gonorrhoeae, which leads to inflammation and purulent discharge in the male and female reproductive tracts.

The bacterium has a number of systems to evade host defenses. Upon infection, it uses pili to adhere to host epithelium. The bacterium also uses an enzyme, gonococcal sialyltransferase, to transfer a sialyic acid residue to a gonococcal surface lipooligosaccharide (LOS). A depiction of this can be seen in Figure 1. The sialyic acid residue mimics the protective capsule found on other bacterial species.

Once infection is established, Neisseria preferentially infects columnar epithelial cells in the female reproductive tract, and leads to a loss of cilia on these cells. Damage to the reproductive tract can result in pelvic inflammatory disease, which can complicate pregnancies later in the life of the woman.

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What is likely true of the lipid A found on the glucosamine molecule in Figure 1?

Possible Answers:

It is synthesized by ribosomes

It contains only nitrogen, carbon, and hydrogen

It is derived from host proteins

It is composed predominately of hydrogens and carbons

It is unable to anchor in the cell membrane due to its hydrophilicity

Correct answer:

It is composed predominately of hydrogens and carbons

Explanation:

Lipids are hydrocarbons, and are the most energy-rich biological macromolecules due to their heavily reduced state. This reduced state is a function of the roughly equal electronegativity between carbon and hydrogen atoms.

Example Question #1 : Properties Of Lipids

Water is the solvent in which all chemical reactions take place for living organisms. In addition, water has a number of critical characteristics that allows it to be invaluable to life as we know it.

Which of the following statements is FALSE concerning the properties of water?

Possible Answers:

Water solvates hydrophobic molecules, such as fatty acids, and separates them.

Water plays a major role in the breakdown of macromolecules.

Water's strong surface tension allows certain bugs to "stand" on the water's surface.

Water's ability to form hydrogen bonds allow it to maintain a liquid state in nature.

Correct answer:

Water solvates hydrophobic molecules, such as fatty acids, and separates them.

Explanation:

Water is able to solvate hydrophilic compounds. Hydrophobic molecules, such as fatty acids, are typically aggregated together by water and can be separated.

Example Question #4 : Properties Of Lipids

Drain cleaners are a common household staple, used to open clogged drains in bathtubs and sinks. Human hair is a common culprit that clogs pipes, and hair is made predominately of protein. Drain cleaners are effective at breaking down proteins that have accumulated in plumbing. Drain cleaners can be either acidic or basic, and are also effective at breaking down fats that have accumulated with proteins.

A typical reaction—reaction 1—which would be expected for a drain cleaner on contact with human hair, would be as follows in an aqueous solution:

Pic_1

Another reaction that may occur, reaction 2, would take place as follows in an aqueous solution:

Pic_2

The drain cleaner in Reaction 1 was used to break down fats as well as the protein depicted. How would the fats be most different in molecular structure?

Possible Answers:

They would be more acidic than the proteins.

They would totally lack any polar bonds.

They would be more reactive than the proteins.

They would be more oxidized than the proteins.

They would have much lower overall polarity in their bonds.

Correct answer:

They would have much lower overall polarity in their bonds.

Explanation:

Fats are less reactive, more reduced, and less acidic than proteins. They have much lower overall polarity, but do contain polar bonds, such as between C and O.

Example Question #11 : Lipids

Water often acts as a reactant or solvent in biological reactions. Which of the following cellular components would not be sufficiently solvated in the body?

Possible Answers:

Nucleotides

Amino acids

Lipids

Carbohydrates

Correct answer:

Lipids

Explanation:

A molecule is solvated when it is surrounded by water molecules, and separated from the other molecules in the body. This separation is possible because of charge or polarity present in the molecule, which causes it to be attractive to water.

Lipids have very low solubility in water due to their nonpolarity. As a result, we conclude that lipids would not be properly solvated in the body, and would instead be clustered together by water molecules.

Example Question #1 : Carbohydrates

Drain cleaners a common household staple, used to open clogged drains in bathtubs and sinks. Human hair is a common culprit that clogs pipes, and hair is made predominately of protein. Drain cleaners are effective at breaking down proteins that have accumulated in plumbing. Drain cleaners can be either acidic or basic, and are also effective at breaking down fats that have accumulated with proteins.

A typical reaction—reaction 1—which would be expected for a drain cleaner on contact with human hair, would be as follows in an aqueous solution:

Pic_1

Another reaction that may occur, reaction 2, would take place as follows in an aqueous solution:

Pic_2

In contrast to the proteins in Reactions 1 and 2, the body uses carbohydrates __________.

Possible Answers:

to store energy for use over many days

to dissolve nonpolar solutes in blood

to create strucutral elements of cells

to function as a secondary energy source after fatty acids have been oxidized

to store energy for immediate use

Correct answer:

to store energy for immediate use

Explanation:

Carboydrates are the main energy currency of cells. They are typically burned first, before fats and proteins, to generate energy. Proteins, in contrast, are usually the functional biomolecules, serving structural and enzymatic roles.

Example Question #1 : Types Of Carbohydrates

Which of the following accurately describes glucose?

Possible Answers:

Aldohexose

Ketohexose

Aldopentose

Ketopentose

Correct answer:

Aldohexose

Explanation:

Glucose is composed of six carbons. When not in ring form, there is an aldehyde at the end of the molecule. As a result, glucose is an example of an aldohexose.

Example Question #1 : Carbohydrates

Which of the following carbohydrates is created in animals, but not in plants?

Possible Answers:

Cellulose

Starch

Amylose

Glycogen

Correct answer:

Glycogen

Explanation:

Glucose is stored in animals cells in the form of glycogen. Plants store glucose as either starch or cellulose. Amylose is a specialized component of starch, and plays a key role in plant energy storage.

Plants do not form glycogen, similar to the way that humans cannot form (or break down) cellulose.

Example Question #1 : Carbohydrates

Which of the following statements is true concerning glucose?

Possible Answers:

Maltose and cellulose differ by the type of linkage between the glucose monomers

-glucopyranose has the anomeric carbon's alcohol group pointing in the opposite direction of the 6th carbon's alcohol group

The 6th carbon attacks the carbonyl carbon in order to create the cyclic structure of glucose

D-glucose has the highest chiral carbon's hydroxyl group pointing to the left

Correct answer:

Maltose and cellulose differ by the type of linkage between the glucose monomers

Explanation:

Maltose and cellulose are both composed of glucose monomers that are combined in a 1,4 glycosidic linkage, however they differ by the type of 1,4 linkage used. Cellulose uses a beta 1,4 linkage, while maltose uses an alpha 1,4 linkage.

Example Question #1671 : Mcat Biological Sciences

Which carbon in a carbohydrate determines whether a human is capable of digesting it properly?

Possible Answers:

The anomeric carbon

The first chiral carbon

All chiral carbons affect its digestion capabilities

The carbonyl carbon

Correct answer:

The first chiral carbon

Explanation:

Humans are only capable of digesting the "D" isomer of a carbohydrate. The carbon that determines whether a carbohydrate is "D" or "L" is the first chiral carbon in the sugar. If it points to the right, the sugar can be digested by humans.

Example Question #1671 : Mcat Biological Sciences

Which type of bond is created between carbohydrates and the sidechain amine of select asparagine residues in proteins?

Possible Answers:

Both are correct

O-glycosidic

N-glycosidic

Neither is correct

Correct answer:

N-glycosidic

Explanation:

A glycosidic bond covalently joins a carbohydrate molecule to another molecule. An O-glycosidic bond is a covalent linkage between a carbohydrate and a protein, joining a serine or threonine hydroxyl side chain and a sugar (oxygen in the bond yields "O"). An N-glycosidic linkage involves bonding of a carbohydrate and a protein, joining an asparagine side chain amide and a sugar (nitrogen in the bond yields "N"). Thus, N-glycosidic is the correct answer.

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