MCAT Biology : Macromolecules

Study concepts, example questions & explanations for MCAT Biology

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Example Questions

Example Question #12 : Nucleic Acids

Prions are the suspected cause of a wide variety of neurodegenerative diseases in mammals. According to prevailing theory, prions are infectious particles made only of protein and found in high concentrations in the brains of infected animals. All mammals produce normal prion protein, PrPC, a transmembrane protein whose function remains unclear. 

Infectious prions, PrPRes, induce conformational changes in the existing PrPC proteins according to the following reaction:

PrPC  + PrPRes  → PrPRes + PrPRes

The PrPRes is then suspected to accumulate in the nervous tissue of infected patients and cause disease. This model of transmission generates replicated proteins, but does so bypassing the standard model of the central dogma of molecular biology. Transcription and translation apparently do not play a role in this replication process.

This theory is a major departure from previously established biological dogma. A scientist decides to test the protein-only theory of prion propagation. He establishes his experiment as follows:

Homogenized brain matter of infected rabbits is injected into the brains of healthy rabbits, as per the following table:

Rabbit 1 and 2: injected with normal saline on days 1 and 2

The above trials serve as controls.

Rabbit 3 and 4: injected with homogenized brain matter on days 1 and 2

The above trials use unmodified brain matter.

Rabbit 5 and 6: injected with irradiated homogenized brain matter on days 1 and 2

The above trials use brain matter that has been irradiated to destroy nucleic acids in the homogenate.

Rabbit 7 and 8: injected with protein-free centrifuged homogenized brain matter on days 1 and 2

The above trials use brain matter that has been centrifuged to generate a protein-free homogenate and a protein-rich homogenate based on molecular weight.

Rabbit 9 and 10: injected with boiled homogenized brain matter on days 1 and 2

The above trials use brain matter that have been boiled to destroy any bacterial contaminants in the homogenate.

In Rabbits 5 and 6, irradiation is used to destroy nucleic acids.  What type of irradiation is likely to be used in this portion of the experiment?

Possible Answers:

All types of radiation have the potential to satisfactorily destroy nucleic acid

Non-ionizing radiation, to prevent free radical generation

Non-ionizing radiation, to generate free radicals

Ionizing radiation, to generate free radicals.

Ionizing radiation, to prevent free radical generation

Correct answer:

Ionizing radiation, to generate free radicals.

Explanation:

Students should be familiar with ionizing radiation as the type of radiation that generates free radicals.  Further, it should be understood that free radical formation causes hyper-reactivity among exisitng nucleic acid molecules and subsequent destruction.

Example Question #1 : Nucleotides And Nucleic Acid Dervatives

How many hydrogen bonds does it take to hold adenine and thymine together? Cytosine and guanine?

Possible Answers:

2; 3

1; 3

2; 2

1; 2

2; 4

Correct answer:

2; 3

Explanation:

In order to hold a base pair together, the hydrogen bond(s) between the bases must be stable. This stability depends on many factors, such as the size and shape of the bases. The adenine-thymine base pair is most stable when held together by 2 hydrogen bonds, while the cytosine-guanine base pair is most stable when held together by 3 hydrogen bonds.

Example Question #1 : Types Of Lipids

Which of the following is not a lipid?

Possible Answers:

Glycine

Prostaglandin

Linolenic acid

Galactocerebroside

Correct answer:

Glycine

Explanation:

Lipids are hydrophobic molecules that have low solubility in water and high solubility in nonpolar organic solvents. The following choices all describe lipid molecules, with the exception of glycine. Glycine is an amino acid and contains a carboxyl group (like fatty acid lipids), but also a amine group. These function groups make glycine hydrophilic and polar, unlike lipids.

Example Question #12 : Functional Group Reactions

Which of the following molecule is a type of terpene?

Possible Answers:

 because it is derived from an isoprene

 because it is derived from a pentene

 because it is derived from an isoprene

 because it is derived from a pentene

Correct answer:

 because it is derived from an isoprene

Explanation:

Terpenes are special classes of lipids that are derived from isoprene units. An isoprene unit’s molecular formula is ; therefore, terpenes must contain a molecular formula that is derived from a empirical formula.

The molecular formula consists of seven isoprene units ( = ); therefore,  is a type of terpene.

Pentene is an alkene with the molecular formula .  () is derived from pentene units; however, terpenes do not have pentene units.

Example Question #2 : Lipids

Drain cleaners a common household staple, used to open clogged drains in bathtubs and sinks. Human hair is a common culprit that clogs pipes, and hair is made predominately of protein. Drain cleaners are effective at breaking down proteins that have accumulated in plumbing. Drain cleaners can be either acidic or basic, and are also effective at breaking down fats that have accumulated with proteins.

A typical reaction—reaction 1—which would be expected for a drain cleaner on contact with human hair, would be as follows in an aqueous solution:

Pic_1

Another reaction that may occur, reaction 2, would take place as follows in an aqueous solution:

Pic_2

The fats that are broken down by drain cleaners in the preceeding passage come predominately from oil secretions in skin and on hair. What is a main function of fats in the body?

Possible Answers:

To store energy in the form of triacylglycerols

To dissolve lipids in the blood

To lubricate joints

To store energy in the form of free fatty acids

To create cytoskeletal elements

Correct answer:

To store energy in the form of triacylglycerols

Explanation:

Of the choices provided, only energy storage in the form of tricacylglycerols makes sense. Free fatty acids do not act as the main storage form for fats, but are used to create triacylglycerols.

Example Question #1 : Properties Of Lipids

Which if the following lipids is responsible for the storing of energy in the body?

Possible Answers:

Sterol lipids

Glycogen

Triacylglycerols

Glycerophospholipids

Eicosanoids

Correct answer:

Triacylglycerols

Explanation:

Triacylglycerols (triglycerides) are composed of three fatty acids and a glycerol backbone. Their primary function is to store energy. As a secondary function they can also provide thermal insulation for an organism.

Phospholipids (glycerophospholipids) are primarily used in the cell membrane, but can also be involved in signaling. Sterol lipids (steroids) are primarily used as hormones, or involved in cell signaling. Eicosanoids are a family of fatty acid involved in signaling.

Glycogen is used to store energy, but it is a carbohydrate glucose polymer. The question specifies that the answer must be a lipid.

Example Question #272 : Organic Chemistry, Biochemistry, And Metabolism

Which of the following best describes steroid molecules?

Possible Answers:

Steroids are nonpolar and can travel across the plasma membrane

Steroids are polar and cannot travel across the plasma membrane

Steroids are polar and can travel across the plasma membrane

Steroids are nonpolar and cannot travel across the plasma membrane

Correct answer:

Steroids are nonpolar and can travel across the plasma membrane

Explanation:

Steroids are a type of lipid. This means that steroids are nonpolar molecules, composed of primarily of hydrogen and carbon. Recall that the interior of the plasma membrane consists of the nonpolar tails of phospholipids. Since nonpolar molecules tend to dissolve in other nonpolar molecules, steroids will be able to traverse the interior (nonpolar phospholipid tail) of plasma membranes and cross into the cell.

Example Question #2 : Properties Of Lipids

Which of the following is false regarding steroids?

Possible Answers:

Steroids are the major component of plasma membranes

Steroid hormones bind to receptors on the nuclear membrane

Steroids and triglycerides are both classified as the same type of macromolecule

All steroids contain at least four rings

Correct answer:

Steroids are the major component of plasma membranes

Explanation:

A steroid is a type of lipid molecule that is found extensively in living organisms. Recall that triglycerides are also a type of lipid; therefore, steroids and triglycerides are classified as the same type of macromolecule. One of the characteristics of steroids is that they have four cycloalkane rings. Three of the four rings are six-membered rings (cyclohexane) and one ring is a five-membered ring (cyclopentane). Steroids are found in several biomolecules, such as hormones. Some examples of steroid hormones include the sex hormones (estrogen, progesterone, and testosterone), aldosterone, and cortisol. Since they are nonpolar, steroid hormones can traverse the lipid bilayer and enter the cell; therefore, the steroid hormone receptors are found inside the cell (on the nuclear membrane).

A type of steroid, called cholesterol, can be found in plasma membranes but it is not the major component of the membrane. Recall that plasma membranes are primarily composed of a phospholipid bilayer; therefore, phospholipids (another type of lipid) are the major component of plasma membranes.

Example Question #3 : Properties Of Lipids

Which of the following will you most likely find in a steroid molecule?

Possible Answers:

Phosphate group

Nitrogenous base

Pentose sugar

Cyclohexane ring

Correct answer:

Cyclohexane ring

Explanation:

Steroids are a type of lipid that are characterized by their four-ring molecular structure. The four rings consist of three six-membered rings and one five-membered ring. Recall that six-membered rings are called cyclohexanes and five-membered rings are called cyclopentanes; therefore, you will most likely find a cyclohexane in a steroid.

Phosphate groups, pentose sugars, and nitrogenous bases are found in nucleotides, which are monomers that make up nucleic acids. Steroids are a type of lipid; therefore, you will most likely not find these substances in a steroid.

Example Question #1 : Lipids

Given the same weight of each, from which macromolecule can the most heat be generated in a combustion reaction?

Possible Answers:

Nucleic acid

Polyunsaturated fat

Saturated fat

Protein 

Carbohydrate

Correct answer:

Saturated fat

Explanation:

The correct answer is saturated fat. Rather than attempting to draw each one of these macromolecules, one should view this conceptually. In a combustion reaction, heat is generated for every carbon-hydrogen bond that is oxidized. In other words, the higher the density of C-H bonds in a compound, the more potential energy it can store. Fats, which primarily consist of only carbon and hydrogen, will contain the most energy and subsequently generate the most heat when oxidized. This is the same reason why animals and plants store energy as fat molecules.

 

*Note: A polyunsaturated fat has more than one double bond between its carbons, which reduces the total number of C-H bonds.

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