Clearly, the use of the adverb "most" indicates that the sentence pertains to a very significant type of loss. The term "loss" can mean merely something that is lost or no longer held in possession, though it could also mean, more strictly, a financial loss. Either sense works in this sentence, though the latter is perhaps more appropriate, given the talk of work and success. In any case, several answers could function as a potential answer for the first blank; however, only "devastating" has a strength that really matches the adverb "most." Something "devastating" is something causing great destruction or shock. Although the second blank could indicate that luck (or something else) is also necessary, it is best to stay with the closest meaning implied by related words in the sentence. The sentence implies that hard work will help to recover from such devastating losses. This would presumably mean that devotion or dedication would likewise help in such a process of recovery.

The general idea of the sentence is that the we could gain much wisdom today by paying attention to the questions asked by the people of the Middle Ages. First, we can say that "critics" is too narrow of a word, as is the paring "philosophical . . . professors." Neither of these are justified by the sentence. When something has relevance today, it can be said to be "contemporary." Something is "contemporary" when it exists (or has implications for) a shared time-frame. It literally is derived from parts meaning "together-time" ("con" + "temporary"). The pair "contemporary . . . generations" well expresses the meaning of the sentence. The thoughts of the people of the Middle Ages have relevance today. They represent a source of wisdom to be taken from previous generations of human thinkers.

The general idea conveyed by this passage is that Laura had changed her manner of judging others. They key fact is that she used to believe people were selfless. Apparently, she thinks that they are now selfish. When we judge people in this manner (always presupposing that they work from selfish motives), we are said to be “cynical.” You might be tempted to choose “condemning.” “Judgment” would work well, but “condemning” does not capture the contrast with her original type of judgment (i.e. that people are generally selfless). Thus “outlook . . . cynical” is the best option.

The general sense of the first sentence is that Thomas made commonplace remarks or statements. A number of the answers fit in this regard (particularly “statements” and “remarks.”) The second part requires slightly more attention. The fact that people had to take time to find the “hidden implications” of his words implies that they contained many points but in a way that was sometimes hidden. "Subtle" thought makes very careful and small distinctions, often to the point of being missed by an untrained mind. This is the best option, far better than “intellectual,” which does not at all express this kind of subtlety. Likewise, “subtle” contrasts well with “commonplace statements,” which at least imply a lack of subtlety.

The most direct clue for this question is “providing indirect confirmation.” The “circumstances” are literally the things "standing around the edges” of something. (In parallel, think of the “circumference” of a circle: it “goes around” its outside.) Circumstantial evidence does not necessarily prove a case, it merely gives evidence that is at best indirect. For instance, a person might have been killed in on a given street, and a potential culprit might regularly walk down that street. However, if that is all that can be gathered, it is at best circumstantial. “Collect” clearly works well.

When faced with a two-word sentence completion question, you often have to examine how the two words fit together, as well as how they fit into the sentence. “Mettle” is a person’s ability to cope, or in other words, their spirit and fortitude; “stoic” means able to endure pain or hardship without complaint. It makes sense that someone’s ability to cope would be tested on the battlefield; likewise, it stands to reason that someone who is “stoic” would have to worry less about how he or she would endure the test of fighting on a battlefield. As for the other answer choices, “debauchery” means immorality or depravity; “heinous” means wicked, evil, and monstrous; “adoration” means love and respect; “jovial” means cheerful; “restraint” means self-control; “sweltering” means very hot; “moderation” means restraint, self-control, or discipline; and “tepid” means lukewarm, or unenthusiastic.

Because this man's perceptive boss is unable to recognize what he is doing, we expect that his behavior is clever and skillfully deceptive. For the first blank, "cunning," "ingenious" (creative and inventive), and "meticulous" (painstakingly careful) would all be consonant with that idea. Of the words corresponding to these three words, only "subterfuge" (dishonest trickery to attain a goal) would work to designate the behavior that these words would describe.

Something that is “higher level” in a given structure could be called the “macrostructure.” The prefix “macro” means larger or longer and is used in words like “macroeconomics” and “macrophage.” If explanations of such structures “must” include that of the simpler ones, the former are directly bound to the latter. If two things are “inextricable,” they cannot be separated from each other. To extricate something is to remove it from things constraining and bound to it.

That a school subject is popular even though it has another characteristic tells us that characteristic should be negative. "Burdensome" and "strenuous" would both work. This makes the options for the second blank "intricacies" and "prowess." "Intricacies" makes more sense in the context of this sentence, because it indicates complexity, where "prowess" indicates skill.

Since Katherine’s work is called impressive, it is likely the case that one could say that she was very careful regarding every detail of the work; therefore, the best option would be to say that she was “assiduous,” meaning that she cared about every detail of the project. Because of this, the option “aspect” fits well with the blank found in the main clause, for such “assiduous care” would imply that no single aspect of the overall project would show any shortfall in quality.