Leading up to ovulation, the developing follicle secretes estrogen. Over time, this secretion increases estrogen concentration. This high concentration of estrogen triggers the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. The spike in LH and FSH concentrations lead to the release of the secondary oocyte from the follicle. Progesterone, on the other hand, is only present at low concentrations at the time of ovulation. Progesterone levels rise after ovulation.

The slow increase in estrogen concentration leading up to ovulation triggers the secretion of luteinizing hormone (LH) from the anterior pituitary gland. The spike in LH initiates signal transduction pathways that release proteolytic enzymes. These enzymes create a hole, or stigma, in the follicle that allows the secondary oocyte to exit.

During the follicular phase of the estrous cycle, estrogen, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) are in a positive feedback loop. High concentrations of estrogen stimulate the anterior pituitary gland to secrete LH and FSH.

The increase in luteinizing hormone (LH) concentration during the follicular stage of the estrous cycle leads to the release of proteolytic enzymes from the follicle. These enzymes degrade the follicle tissue and create a hole called the “stigma.” The secondary oocyte exits the follicle from the stigma in a process called ovulation.

Semen is a fluid that contains sperm cells, proteolytic enzymes, lipids, and fructose. The prostate gland, bulbourethral gland, and seminal vesicles all contribute to the makeup of semen. Semen protects and transports sperm cells inside the female reproductive tract as they seek out the egg cell.

Semen is the fluid that contains and transports sperm cells to the female reproductive tract. The female vagina is acidic due to lactic acid output from normally occurring bacteria in the vagina. In order to protect sperm cells from the acidic environment, semen is alkaline.

The bulbourethral gland is a part of the male reproductive system that contributes protein-rich fluid to semen and lubricates the urethra.

Prior to ejaculation, secretions from the bulbourethral gland, prostate gland, epididymis, and seminal vesicles enter the ejaculatory duct. The ejaculatory duct is the place where semen mixes and is stored until ejaculation.

Seminal vesicles secrete a large portion of the components that make up semen. A high concentration of fructose is included in these secretions. The fructose provides energy rich molecules for sperm cell movement.

In males, the urethra carries semen from the ejaculatory duct out of the penis. The urethra also carries urine from the bladder through the penis.