Biochemistry : Reactants and Products of the Citric Acid Cycle

Study concepts, example questions & explanations for Biochemistry

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Example Questions

Example Question #11 : Reactants And Products Of The Citric Acid Cycle

The pyruvate dehydrogenase complex creates acetyl-CoA from pyruvate. What other molecule is a product of this reaction?

Possible Answers:

Correct answer:

Explanation:

Pyruvate is converted to acetyl-CoA by the pyruvate dehydrogenase complex. Carbon dioxide is released during this reaction, and in addition to this,  is reduced to .

Example Question #42 : Citric Acid Cycle

In what part of the cell does the pyruvate dehydrogenase complex function?

Possible Answers:

Within the inner membrane of the mitochondria

The mitochondrial intermembrane

Cytoplasm

In the nucleus

The mitochondrial matrix

Correct answer:

The mitochondrial matrix

Explanation:

The pyruvate dehydrogenase complex (PDC) is preparing pyruvate for the Krebs cycle by converting it to acetyl-CoA. Because the Krebs cycle functions within the mitochondrial matrix, the PDC is also taking place there.  This ensures quick and easy movement from the PDC into the Krebs cycle.

Example Question #43 : Citric Acid Cycle

Which process involved in cellular respiration produces the largest quantity of high energy electron carriers?

Possible Answers:

Pyruvate dehydrogenase complex

Glycolysis

ATP synthase

Krebs cycle

Electron transport chain

Correct answer:

Krebs cycle

Explanation:

The Krebs cycle produces the most high energy electron carriers of any process involved in cellular respiration. Per glucose molecule, the Krebs cycle produces  and .

Example Question #44 : Citric Acid Cycle

Which of the following molecules enter the Krebs cycle directly, following glycolysis?

Possible Answers:

Glucose

Acetyl-CoA

Pyruvate

Pyruvate dehydrogenase

Ubiquinone

Correct answer:

Acetyl-CoA

Explanation:

Ubiquinone is a part of the electron transport chain, and has little to do with the Krebs cycle. Glucose is broken down during glycolysis, and does not enter the Krebs cycle directly. Many students make the mistake of thinking that pyruvate enters the Krebs cycle, since it is produced in glycolysis, and the Krebs cycle follows glycolysis. However, pyruvate is first converted to acetyl-CoA by the pyruvate dehydrogenase complex in the mitochondrial matrix, and acetyl-CoA enters the Krebs cycle.

Example Question #15 : Reactants And Products Of The Citric Acid Cycle

What is the role of isocitrate dehydrogenase in the citric acid cycle of the mitochondria?

Possible Answers:

Isocitrate dehydrogenase converts citrate to alpha-ketoglutarate and is inhibited by 

Isocitrate dehydrogenase converts alpha-ketoglutarate to isocitrate and is activated by 

Isocitrate dehydrogenase converts isocitrate to alpha-ketoglutarate and is inhibited by 

Isocitrate dehydrogenase converts citrate to isocitrate and is inhibited by 

Isocitrate dehydrogenase converts citrate to isocitrate and is activated by

Correct answer:

Isocitrate dehydrogenase converts isocitrate to alpha-ketoglutarate and is inhibited by 

Explanation:

Isocitrate dehydrogenase activation leads to oxidative decarboxylation of isocitrate in a two step process producing alpha-ketoglutarate and . In the mitochondria, the reaction produces also a charged electron carrier molecule, , from . Isocitrate dehydrogenase, inhibited by  and activated by , is a major regulator enzyme of the citric cycle.

Example Question #961 : Biochemistry

Which of the following steps within the citric acid cycle results in the production of a molecule of carbon dioxide ?

Possible Answers:

The conversion of malate to oxaloacetate

The conversion of succinyl-CoA to succinate

The conversion of isocitrate to alpha-ketoglutarate 

The conversion of succinate to fumarate

The conversion of fumarate to malate

Correct answer:

The conversion of isocitrate to alpha-ketoglutarate 

Explanation:

The only step of the citric acid cycle listed that results in the production of  as a side product is the conversion of isocitrate to alpha-ketoglutarate. In this step, the enzyme, isocitrate dehydrogenase catalyzes the conversion of isocitrate to alpha-ketoglutarate, while also converting  to  and  as side products, and generating a molecule of  in the process (i.e. reducing the carbon count from 5 in isocitrate to 4 in alpha-ketoglutarate). 

The conversion of alpha-ketoglutarate to succinyl-CoA also produces a molecule of  as a side product. However, this step is not listed as an answer choice.

None of the other answer choices listed produce  as side products. 

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