All Biochemistry Resources
Example Questions
Example Question #1 : Molecular Bonds And Forces
Which of the following types of bonding or interactions does not usually characterize the interactions which occur between an enzyme's active site and its substrate?
All of these bond types are exhibited in enzyme-substrate binding.
Hydrogen bonding
Van der Waals interactions
Hydrophobic interactions
Covalent bonding
Covalent bonding
Covalent bonding is too strong to allow for the enzyme to subsequently release the substrate or product (depending on if the initial substrate or eventual product does the covalent bonding). Thus, it permanently inhibits the enzyme active site and prevents it from continuing its activity. All of the other interactions are much weaker and allow the enzyme to release the product. They are all ways in which active sites interact with their substrates.
Example Question #1 : Hydrogen Bonds
Which of the following most correctly describes hydrogen bonding?
A partially positive hydrogen attracts a lone electron pair from a partially positive atom
A partially negative hydrogen attracts a lone electron pair from a partially negative atom
A partially positive hydrogen attracts a lone electron pair from a partially negative atom
A partially negative hydrogen attracts a lone electron pair from a partially positive atom
A neutral hydrogen attracts a lone electron pair from a charged atom
A partially positive hydrogen attracts a lone electron pair from a partially negative atom
Hydrogen bonding occurs when a molecule contains a hydrogen atom bonded to fluorine, oxygen, or nitrogen. This hydrogen becomes partially positive in charge, while the attached atom becomes partially negative. This is due to unequal electronegativity causing increased electron density for the more electronegative atom, and therefore a more negative charge. The partially positive charge then forms an electrostatic attraction to another partially negative atom nearby.
Example Question #2 : Hydrogen Bonds
In the DNA double-helix structure, what kind of bonds connect the complementary bases together?
Ionic bonds
Phosphodiester bonds
None of these answers
Hydrogen bonds
Covalent bonds
Hydrogen bonds
In the double-helix structure of DNA, there are 2 hydrogen bonds between adenine and thymine, and 3 hydrogen bonds between cytosine and guanine. Phosphodiester bonds are covalent bonds between the 5-C sugar and phosphate group of nucleotides (and are much stronger than the hydrogen bonds between complementary bases).
Example Question #1 : Hydrogen Bonds
What is not true about hydrogen bonds?
Hydrogen bonds are found between water molecules
Hydrogen bonds can be found between metals
Hydrogen bonds increase the boiling point of water
Hydrogen bonds are found in DNA structure
Hydrogen bonds are found in protein structure
Hydrogen bonds can be found between metals
Hydrogen bonds are found in primary structure of protein, as well as between the bases in DNA structure. Hydrogen bonds are only found between hydrogens attached to oxygen, nitrogen, or fluorine. They increase the attraction between water molecules, therefore are harder to break in large numbers, causing an increase in boiling point.
Example Question #1 : Hydrogen Bonds
In a solution of water, which of the following amino acids do you expect to be on the outside of a protein in its native state?
Valine
Phenylalanine
Isoleucine
Glutamic acid
Glutamic acid
In a solution of water, the outside of a folded protein is going to be in direct contact with water. Therefore, polar or ionic attractions are most favored on the outside of a protein in a solution of water since these can form attractions. The only amino acid listed that can form either polar or ionic attractions is glutamic acid.
Example Question #1 : Hydrogen Bonds
A researcher adds three molecules together and notices no reactions. Upon further analysis, he notices that molecule A and molecule B form strong intermolecular bonds whereas molecule C doesn’t form any bonds between A and B. Which of the following might be true regarding these three molecules?
I. Molecule A might have nitrogen
II. Molecule B might have fluorine
III. Molecule C might have nitrogen
I and III
II and III
I and II
I, II and III
I and II
An example of strong intermolecular bond is a hydrogen bond. A hydrogen bond occurs between a hydrogen atom on a molecule and an either nitrogen, oxygen, or fluorine atom on an adjacent molecule. The question states that there are bonds between molecule A and molecule B. We can assume that these are hydrogen bonds. This means that molecule A can have hydrogen atom and/or nitrogen, oxygen, or fluorine atoms. Similarly, molecule B can also have hydrogen atom and/or nitrogen, oxygen, or fluorine atoms.
Molecule C doesn’t form hydrogen bonds with either of the other two molecules. This means it cannot have hydrogen and/or nitrogen, oxygen, or fluorine atoms. This is because if molecule C had any of these atoms then it would interact with at least one of the other molecules and form hydrogen bonds (because molecule A and molecule B have these other atoms).
Example Question #1 : Hydrogen Bonds
Classically, covalent bonds are considered __________ bonds and hydrogen bonds are __________.
intermolecular . . . intramolecular
intramolecular . . . intramolecular
intramolecular . . . intermolecular
intermolecular . . . intermolecular
intramolecular . . . intermolecular
Covalent bonds occur between atoms within (or intra) molecules. This means that covalent bonds are intramolecular bonds. Hydrogen bonds, on the other hand, occur between hydrogen atoms of one molecule and either a nitrogen, an oxygen, or a fluorine atom in another molecule. Since hydrogen bonds occur between molecules, they are classified as intermolecular bonds. There are some situations in which hydrogen bonds may be formed intramolecularly, but these are special cases.
Example Question #4 : Hydrogen Bonds
A student notes that a molecule forms hydrogen bonds that involve chlorine atoms. What can you conclude about this observation?
This observation is invalid because chlorine cannot form hydrogen bonds due to its smaller electronegativity
This observation is valid
This observation is invalid because chlorine is a halogen and cannot form hydrogen bonds
The observation is invalid because chlorine cannot form hydrogen bonds because it is a gas at room temperature
This observation is invalid because chlorine cannot form hydrogen bonds due to its smaller electronegativity
Hydrogen bonds occur between a hydrogen atom in one molecule and either nitrogen, oxygen, or fluorine atom in another molecule. It only involves nitrogen, oxygen, or fluorine atoms because these atoms have high electronegativity. Since they have very high electronegativity, these three atoms can easily attract the electron found in the hydrogen atom and form hydrogen bonds. Chlorine doesn’t have high enough electronegativity to form hydrogen bonds.
An atom's state of matter does not determine whether an atom can form hydrogen bonds. Fluorine, just like chlorine, is a halogen and it can form hydrogen bonds.
Example Question #2 : Hydrogen Bonds
Which of the following is not true about hydrogen bonds?
Bond strength is partially determined by the bond angle
They contribute to the three dimensional structures of larger macromolecules
They are stronger than van der Waals interactions
They can only form intramolecularly
They can form both intermolecularly and intramolecularly
They can only form intramolecularly
Hydrogen bonds can occur between two molecules (intermolecular) and within parts of a single molecule (intramolecular). They are weaker than covalent bonds but are stronger than a Van der Waals interaction, and this strength is determined by a number of factors including bond angle.
Example Question #2 : Hydrogen Bonds
Hydrogen bonds mostly occur between hydrogen and which other atoms?
Sodium, magnesium and aluminum
Scandium and vanadium
Silicon and Germanium
Neon, argon, and xenon
Oxygen, nitrogen, and fluorine
Oxygen, nitrogen, and fluorine
For a hydrogen bond to occur, the atom to which the hydrogen is bonded has to have a high relative Pauling electronegativity. Only oxygen, nitrogen, and fluorine, in the upper right corner of the periodic table, have these electronegativities. Neon, argon, and xenon are, of course, inert noble gases, although xenon is sometimes assigned a high electronegativity. This is due, however, to rare bonding events -- certainly not regular hydrogen bonding. Sodium, magnesium and aluminum often form positively charged ions, so they would not tend to attract a hydrogen nucleus.
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