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Example Questions
Example Question #1 : Understand Pyruvate Decarboxylation
During pyruvate decarboxylation reaction, pyruvate is converted to _______________ compound, through a reaction called ______________ .
acetyl CoA; oxidative decarboxylation
NADH; oxidative decarboxylation
ATP; decomposition
acetyl CoA; reductive decarboxylation
acetyl CoA; oxidative decarboxylation
Pyruvate decarboxylation is an oxidative decarboxylation reaction, or an oxidation reaction where a carboxylate group is removed. This reaction converts pyruvate which was produced through glycolysis to acetyl CoA to be used in the Citric Acid Cycle.
Example Question #2 : Understand Pyruvate Decarboxylation
Which enzyme complex catalyzes the pyruvate decarboxylation reaction?
pyruvate dehydrogenase complex
pyruvate oxidase
pyruvate reductase
acetyl dehydrogenase
pyruvate dehydrogenase complex
The pyruvate dehydrogenase complex is an enzyme complex that consists of 3 enzymes, which work together to catalyze the pyruvate decarboxylation reaction, where pyruvate is converted to acetyl CoA.
Example Question #3 : Understand Pyruvate Decarboxylation
Where does the pyruvate decarboxylation reaction occur?
Outer mitochondrial membrane
Cytosol
Cristae
Mitochondrial matrix
Mitochondrial matrix
Pyruvate decarboxylation occurs in the mitochondrial matrix. The acetyl CoA produced from the pyruvate decarboxylation reaction will undergo the Citric Acid cycle also in the mitochondrial matrix.
Example Question #4 : Understand Pyruvate Decarboxylation
For each glucose molecule that undergoes glycolysis, how many acetyl CoA molecules are produced at the end of pyruvate decarboxylation?
4
32
1
2
2
During glycolysis, for each molecule of glucose, two molecules of pyruvate are produced ( glucose+ NAD+ + 2 ADP + 2Pi-> 2 pyruvate+ 2 ATP + 2NADH+. These 2 molecules of pyruvate then undergo the pyruvate decarboxylation reaction: 2(pyruvate+ CoA-SH+ NAD+ -> NADH+ CO2+ acetyl CoA).
Example Question #5 : Understand Pyruvate Decarboxylation
During the pyruvate decarboxylation reaction, acetyl CoA is produced through which type of bond linking an acetyl group to coenzyme A?
hydrogen bond
thioester bond
acetylase bond
ionic bond
thioester bond
During the pyruvate decarboxylation reaction , a thioester bond links the acetyl group of pyruvate with coenzyme A to produce acetyl CoA.
Example Question #6 : Understand Pyruvate Decarboxylation
Which is not a product of pyruvate decarboxylation reaction?
acetyl
The pyruvate decarboxylation reaction is pyruvate+ CoA-SH+ NAD+ -> NADH+ CO2+ acetyl CoA.
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