"The Cell Cycle" by Joseph Ritchie (2014)

The process by which cells divide and multiply is known as the cell cycle. This cycle consists of two main phases: interphase and mitosis. Each phase consists of a series of clearly defined and observable steps. At the conclusion of the cycle, each parent cell produces two genetically identical daughter cells that may also replicate by proceeding through the cell cycle.

Roughly ninety percent of the cell cycle is spent in interphase. Interphase is comprised of three main steps: the first gap phase, the synthesis phase (also called "S phase"), and the second gap phase. The initial gap phase is a period of cellular preparation in which the cell increases in size and readies itself for DNA synthesis. In the synthesis phase, or S phase, DNA replication occurs, so that when the cell divides, each daughter cell will have the DNA necessary to function properly. In the second gap phase, the cell grows in size and prepares for cellular division in the mitotic phase. At the end of each gap phase, the cell has to pass a regulatory checkpoint to ensure that nothing is going wrong. If anything has gone wrong, the checkpoints stop the cell from proceeding through the cell cycle any further.

The next part of the cell cycle is mitosis. Mitosis is a form of cell division and is broken down into five distinct phases. During prophase, the genetic material contained in the cell’s chromatin condenses into distinct chromosomes. Prometaphase is marked by the breakdown of the cell’s nuclear envelope and the formation of centrosomes at the poles of the cell. During metaphase, the cell’s chromosomes are moved to the center of the cell. A checkpoint ensures that the chromosomes are properly aligned on the center and halts the cell cycle if any errors have occurred. In anaphase, chromosomes break apart at their center, or centromere, and sister chromatids move to opposite ends of the cell. Lastly, telophase and cytokinesis occur as nuclear membranes form to physically divide the cell into two new daughter cells. Chromosomes also unwind into loose chromatin during this part of mitosis. Cytokinesis is defined as the division of the each cell’s cytoplasm and organelles. At the conclusion of the cell cycle, two genetically identical daughter cells have formed.

The cell cycle operates by a series of checkpoints and external cues. This system of checks enables the cell to enter a state of dormancy known as the gap zero phase when conditions or other factors inhibit the cell cycle. Conversely, unregulated and uncontrolled cellular division can occur under certain circumstances. A cell in a state of uncontrolled division is known to be cancerous. Lastly, cells have the ability to mediate their own death by way of apoptosis if certain genetic or physical abnormalities exist. The cell cycle is a complex process that enables cells to replicate and proliferate under a stringent set of checks and balances that produce healthy and viable daughter cells that are each able to perform the process in the future.

Cytokinesis is best defined as which of the following?

Adapted from Volume Four of The Natural History of Animals: The Animal Life of the World in Its Various Aspects and Relations by James Richard Ainsworth Davis (1903)

The examples of protective resemblance so far quoted are mostly permanent adaptations to one particular sort of surrounding. There are, however, numerous animals which possess the power of adjusting their color more or less rapidly so as to harmonize with a changing environment.

Some of the best known of these cases are found among those mammals and birds that inhabit countries more or less covered with snow during a part of the year. A good instance is afforded by the Irish or variable hare, which is chiefly found in Ireland and Scotland. In summer, this looks very much like an ordinary hare, though rather grayer in tint and smaller in size, but in winter it becomes white with the exception of the black tips to the ears. Investigations that have been made on the closely allied American hare seem to show that the phenomenon is due to the growth of new hairs of white hue. 

The common stoat is subject to similar color change in the northern parts of its range. In summer it is of a bright reddish brown color with the exception of the under parts, which are yellowish white, and the end of the tail, which is black. But in winter, the entire coat, save only the tip of the tail, becomes white, and in that condition the animal is known as an ermine. A similar example is afforded by the weasel. The seasonal change in the vegetarian Irish hare is purely of protective character, but in such an actively carnivorous creature as a stoat or weasel, it is aggressive as well, rendering the animal inconspicuous to its prey.

Which of the following terms is closest in meaning to the underlined word “inconspicuous”?

Adapted from Essays on Early Ornithology and Kindred Subjects by James R. McClymont (1920)

The voyagers named it the Angra de Santa Elena, and it may have been the bay which is now known as St. Helen’s Bay. But it is worthy of note that the G. de Sta. Ellena of the Cantino Chart is laid down in a position which corresponds rather with that of Table Bay than with that of St. Helen’s Bay.

The Portuguese came into contact with the inhabitants of the country adjacent to the anchorage. These people had tawny complexions, and carried wooden spears tipped with horn—assagais of a kind—and bows and arrows. They also used foxes’ tails attached to short wooden handles. We are not informed for what purposes the foxes’ tails were used. Were they used to brush flies away, or were they insignia of authority? The food of the natives was the flesh of whales, seals, and antelopes (gazellas), and the roots of certain plants. Crayfish or ‘Cape lobsters’ abounded near the anchorage.

The author of the roteiro affirms that the birds of the country resembled the birds in Portugal, and that amongst them were cormorants, larks, turtle-doves, and gulls. The gulls are called "guayvotas," but "guayvotas" is probably another instance of the eccentric orthography of the author and equivalent to "gaivotas."

In December the squadron reached the Angra de São Bràs, which was either Mossel Bay or another bay in close proximity to Mossel Bay. Here penguins and seals were in great abundance. The author of the roteiro calls the penguins "sotelycairos," which is more correctly written "sotilicarios" by subsequent writers. The word is probably related to the Spanish "sotil" and the Latin "subtilis," and may contain an allusion to the supposed cunning of the penguins, which disappear by diving when an enemy approaches.

The sotilicarios, says the chronicler, could not fly because there were no quill-feathers in their wings; in size they were as large as drakes, and their cry resembled the braying of an ass. Castanheda, Goes, and Osorio also mention the sotilicario in their accounts of the first voyage of Vasco da Gama, and compare its flipper to the wing of a bat—a not wholly inept comparison, for the under-surface of the wings of penguins is wholly devoid of feathery covering. Manuel de Mesquita Perestrello, who visited the south coast of Africa in 1575, also describes the Cape penguin. From a manuscript of his Roteiro in the Oporto Library, one learns that the flippers of the sotilicario were covered with minute feathers, as indeed they are on the upper surface and that they dived after fish, upon which they fed, and on which they fed their young, which were hatched in nests constructed of fishbones. There is nothing to cavil at in these statements, unless it be that which asserts that the nests were constructed of fishbones, for this is not in accordance with the observations of contemporary naturalists, who tell us that the nests of the Cape Penguin (Spheniscus demersus) are constructed of stones, shells, and debris. It is, therefore, probable that the fishbones which Perestrello saw were the remains of repasts of seals.

Seals, says the roteiro, were in great number at the Angra de São Bràs. On one occasion the number was counted and was found to be three thousand. Some were as large as bears and their roaring was as the roaring of lions. Others, which were very small, bleated like kids. These differences in size and in voice may be explained by differences in the age and in the sex of the seals, for seals of different species do not usually resort to the same locality. The seal which formerly frequented the south coast of Africa—for it is, I believe, no longer a denizen of that region—was that which is known to naturalists as Arctocephalus delalandii, and, as adult males sometimes attain eight and a half feet in length, it may well be described as of the size of a bear. Cubs from six to eight months of age measure about two feet and a half in length. The Portuguese caught anchovies in the bay, which they salted to serve as provisions on the voyage. They anchored a second time in the Angra de São Bràs in March, 1499, on their homeward voyage.

Yet one more allusion to the penguins and seals of the Angra de São Bràs is of sufficient historical interest to be mentioned. The first Dutch expedition to Bantam weighed anchor on the 2nd of April, 1595, and on the 4th of August of the same year the vessels anchored in a harbor called "Ague Sambras," in eight or nine fathoms of water, on a sandy bottom. So many of the sailors were sick with scurvy—"thirty or thirty-three," said the narrator, "in one ship"—that it was necessary to find fresh fruit for them. "In this bay," runs the English translation of the narrative, "lieth a small Island wherein are many birds called Pyncuins and sea Wolves that are taken with men’s hands." In the original Dutch narrative by Willem Lodewyckszoon, published in Amsterdam in 1597, the name of the birds appears as "Pinguijns."

The underlined word “cavil” most nearly means __________.

Adapted from Essays on Early Ornithology and Kindred Subjects by James R. McClymont (1920)

The voyagers named it the Angra de Santa Elena, and it may have been the bay which is now known as St. Helen’s Bay. But it is worthy of note that the G. de Sta. Ellena of the Cantino Chart is laid down in a position which corresponds rather with that of Table Bay than with that of St. Helen’s Bay.

The Portuguese came into contact with the inhabitants of the country adjacent to the anchorage. These people had tawny complexions, and carried wooden spears tipped with horn—assagais of a kind—and bows and arrows. They also used foxes’ tails attached to short wooden handles. We are not informed for what purposes the foxes’ tails were used. Were they used to brush flies away, or were they insignia of authority? The food of the natives was the flesh of whales, seals, and antelopes (gazellas), and the roots of certain plants. Crayfish or ‘Cape lobsters’ abounded near the anchorage.

The author of the roteiro affirms that the birds of the country resembled the birds in Portugal, and that amongst them were cormorants, larks, turtle-doves, and gulls. The gulls are called "guayvotas," but "guayvotas" is probably another instance of the eccentric orthography of the author and equivalent to "gaivotas."

In December the squadron reached the Angra de São Bràs, which was either Mossel Bay or another bay in close proximity to Mossel Bay. Here penguins and seals were in great abundance. The author of the roteiro calls the penguins "sotelycairos," which is more correctly written "sotilicarios" by subsequent writers. The word is probably related to the Spanish "sotil" and the Latin "subtilis," and may contain an allusion to the supposed cunning of the penguins, which disappear by diving when an enemy approaches.

The sotilicarios, says the chronicler, could not fly because there were no quill-feathers in their wings; in size they were as large as drakes, and their cry resembled the braying of an ass. Castanheda, Goes, and Osorio also mention the sotilicario in their accounts of the first voyage of Vasco da Gama, and compare its flipper to the wing of a bat—a not wholly inept comparison, for the under-surface of the wings of penguins is wholly devoid of feathery covering. Manuel de Mesquita Perestrello, who visited the south coast of Africa in 1575, also describes the Cape penguin. From a manuscript of his Roteiro in the Oporto Library, one learns that the flippers of the sotilicario were covered with minute feathers, as indeed they are on the upper surface and that they dived after fish, upon which they fed, and on which they fed their young, which were hatched in nests constructed of fishbones. There is nothing to cavil at in these statements, unless it be that which asserts that the nests were constructed of fishbones, for this is not in accordance with the observations of contemporary naturalists, who tell us that the nests of the Cape Penguin (Spheniscus demersus) are constructed of stones, shells, and debris. It is, therefore, probable that the fishbones which Perestrello saw were the remains of repasts of seals.

Seals, says the roteiro, were in great number at the Angra de São Bràs. On one occasion the number was counted and was found to be three thousand. Some were as large as bears and their roaring was as the roaring of lions. Others, which were very small, bleated like kids. These differences in size and in voice may be explained by differences in the age and in the sex of the seals, for seals of different species do not usually resort to the same locality. The seal which formerly frequented the south coast of Africa—for it is, I believe, no longer a denizen of that region—was that which is known to naturalists as Arctocephalus delalandii, and, as adult males sometimes attain eight and a half feet in length, it may well be described as of the size of a bear. Cubs from six to eight months of age measure about two feet and a half in length. The Portuguese caught anchovies in the bay, which they salted to serve as provisions on the voyage. They anchored a second time in the Angra de São Bràs in March, 1499, on their homeward voyage.

Yet one more allusion to the penguins and seals of the Angra de São Bràs is of sufficient historical interest to be mentioned. The first Dutch expedition to Bantam weighed anchor on the 2nd of April, 1595, and on the 4th of August of the same year the vessels anchored in a harbor called "Ague Sambras," in eight or nine fathoms of water, on a sandy bottom. So many of the sailors were sick with scurvy—"thirty or thirty-three," said the narrator, "in one ship"—that it was necessary to find fresh fruit for them. "In this bay," runs the English translation of the narrative, "lieth a small Island wherein are many birds called Pyncuins and sea Wolves that are taken with men’s hands." In the original Dutch narrative by Willem Lodewyckszoon, published in Amsterdam in 1597, the name of the birds appears as "Pinguijns."

As it is used in the passage, the underlined word “denizen” most nearly means __________.

Adapted from “Birds in Retreat” in “Animal Defences—Active Defence” in Volume Four of The Natural History of Animals: The Animal Life of the World in Its Various Aspects and Relations by James Richard Ainsworth Davis (1903)

Among the large running birds are forms, like the African ostrich, in which the absence of powers of flight is largely compensated by the specialization of the legs for the purpose of rapid movement on the ground. For straightforward retreat in open country nothing could be more effective; but another kind of adaptation is required in birds like rails, which are deficient in powers of flight, and yet are able to run through thickly-growing vegetation with such rapidity as to commonly elude their enemies. This is rendered possible by the shape of their bodies, which are relatively narrow and flattened from side to side, so as to easily slip between the stems of grasses, rushes, and similar plants. Anyone who has pursued our native land-rail or corn-crake with intent to capture will have noted how extremely difficult it is even to get within sight of a bird of this sort. 

Certain birds, unfortunately for themselves, have lost the power of flight without correspondingly increased powers of running, and have paid the penalty of extinction. Such an arrangement, as might be anticipated, was the result of evolution in islands devoid of any predatory ground-animals, and a classic example of it is afforded by the dodo and its allies, birds related to the pigeons. The dodo itself was a large and clumsy-looking species that at one time abounded in the island of Mauritius, which, like oceanic islands generally, possessed no native mammals, while its indigenous reptiles were only represented by lizards. The ubiquitous sailor, however, and the animals (especially swine) which he introduced, brought about the extinction of this helpless bird in less than a century after its first discovery in 1598. Its memory is now only kept green by a few contemporary drawings and descriptions, certain museum remains, and the proverb "as extinct as a dodo.” A similar fate must overtake any organism suddenly exposed to new and unfavorable conditions, if devoid of sufficient plasticity to rapidly accommodate itself to the altered environment.

Based on the way in which it is used in the passage, what is the meaning of the underlined word “ubiquitous”?

Adapted from "Taking a Second Look: An Analysis of Genetic Markers in Species Relatedness" by Joseph Ritchie (2014)

Phylogenetics is the study of genetic composition in various species and is used by evolutionary biologists to investigate similarities in the molecular sequences of proteins in varying organisms. The amino acid sequences that build proteins are used to construct mathematical matrices that aid in determining evolutionary ties through the investigation of percentage similarities. The study of these matrices helps to expose evolutionary relationships between species that may not have the same overt characteristics.

Species adapt and evolve based on the pressures that exist in their environment. Climate, food source, and habitat availability are only a few factors that act on species adaptation. These stressors can alter the physical characteristics of organisms. This divergence in evolution has made it difficult to determine the interrelatedness of organisms by analyzing their physical characteristics alone.

For instance, looking only at physical characteristics, the ghost bat resembles a pigeon more than a spider monkey; however, phylogenetics has found that the amino acid sequences that construct the beta hemoglobin molecules of bats are twenty percent more similar to those of mammalian primates than those of birds. This helps reject the assumption that common physical characteristics between species are all that is needed to determine relatedness. 

The differences produced by divergent evolution observed in the forest-dwelling, arboreal spider monkey and the nocturnal, airborne ghost bat can be reconciled through homology. Homologous characteristics are anatomical traits that are similar in two or more different species. For instance, the bone structure of a spider monkey’s wrist and fingers greatly resembles that of a bat’s wing or even a whale’s fin. These similarities are reinforced by phylogenetic evidence that supports the idea that physically dissimilar species can be evolutionarily related through anatomical and genetic similarities.

The underlined word "divergent" in paragraph four most nearly means which of the following?

Adapted from "Taking a Second Look: An Analysis of Genetic Markers in Species Relatedness" by Joseph Ritchie (2014)

Phylogenetics is the study of genetic composition in various species and is used by evolutionary biologists to investigate similarities in the molecular sequences of proteins in varying organisms. The amino acid sequences that build proteins are used to construct mathematical matrices that aid in determining evolutionary ties through the investigation of percentage similarities. The study of these matrices helps to expose evolutionary relationships between species that may not have the same overt characteristics.

Species adapt and evolve based on the pressures that exist in their environment. Climate, food source, and habitat availability are only a few factors that act on species adaptation. These stressors can alter the physical characteristics of organisms. This divergence in evolution has made it difficult to determine the interrelatedness of organisms by analyzing their physical characteristics alone.

For instance, looking only at physical characteristics, the ghost bat resembles a pigeon more than a spider monkey; however, phylogenetics has found that the amino acid sequences that construct the beta hemoglobin molecules of bats are twenty percent more similar to those of mammalian primates than those of birds. This helps reject the assumption that common physical characteristics between species are all that is needed to determine relatedness. 

The differences produced by divergent evolution observed in the forest-dwelling, arboreal spider monkey and the nocturnal, airborne ghost bat can be reconciled through homology. Homologous characteristics are anatomical traits that are similar in two or more different species. For instance, the bone structure of a spider monkey’s wrist and fingers greatly resembles that of a bat’s wing or even a whale’s fin. These similarities are reinforced by phylogenetic evidence that supports the idea that physically dissimilar species can be evolutionarily related through anatomical and genetic similarities.

The underlined word "overt" in paragraph one most nearly means which of the following?