MCAT Biology : Biochemistry and Metabolism

Study concepts, example questions & explanations for MCAT Biology

varsity tutors app store varsity tutors android store

Example Questions

Example Question #1 : Lipids And Metabolism

In which of the following places does the breakdown phase of beta-oxidation occur?

Possible Answers:

Cytosol

Nucleus

Endoplasmic reticulum

Mitochondrial matrix

Mitochondrial intermembrane space

Correct answer:

Mitochondrial matrix

Explanation:

Beta-oxidation is the metabolization of fatty acids to generate acetyl CoA, which can be used in the Krebs cycle. This process always occurs in the mitochondrial matrix.

Example Question #2 : Lipids And Metabolism

Which of the following describes a beta oxidation reaction?

Possible Answers:

Glucose is converted to glycogen

Protein is converted to alpha-keto acid

Acetyl-CoA is converted to fatty acid

Fatty acid is converted to acetyl-CoA

Glycogen is converted to glucose

Correct answer:

Fatty acid is converted to acetyl-CoA

Explanation:

Beta oxidation is the process by which fatty acid molecules are broken down in the mitochondria to produce acetyl-coA, which can then enter the citric acid (Krebs) cycle. The correct transition from reactant to product for beta oxidation is fatty acid to acetyl-CoA.

Example Question #5 : Lipids And Metabolism

Fatty acids and cholesterol are stored in tissues as __________ and __________, respectively.

Possible Answers:

eicosanoids . . . triacylglycerols 

triacylglycerols . . . cholesteryl esters

triacylglycerols . . . high-density lipoprotein (HDL)

sphingolipids . . . cholesteryl esters

cholesteryl esters . . . ketone bodies 

Correct answer:

triacylglycerols . . . cholesteryl esters

Explanation:

Fatty acids are stored as triacylglycerols in adipose tissue, while cholesterol is stored as cholesteryl esters in a number of different tissues. Both fatty acids and cholesterol are hydrophobic molecules, which is why they are stored as lipid droplets within their respective tissues. 

Example Question #2 : Lipids And Metabolism

The cellular membrane is a very important structure. The lipid bilayer is both hydrophilic and hydrophobic. The hydrophilic layer faces the extracellular fluid and the cytosol of the cell. The hydrophobic portion of the lipid bilayer stays in between the hydrophobic regions like a sandwich. This bilayer separation allows for communication, protection, and homeostasis. 

One of the most utilized signaling transduction pathways is the G protein-coupled receptor pathway. The hydrophobic and hydrophilic properties of the cellular membrane allows for the peptide and other hydrophilic hormones to bind to the receptor on the cellular surface but to not enter the cell. This regulation allows for activation despite the hormone’s short half-life. On the other hand, hydrophobic hormones must have longer half-lives to allow for these ligands to cross the lipid bilayer, travel through the cell’s cytosol and eventually reach the nucleus. 

Cholesterol allows the lipid bilayer to maintain its fluidity despite the fluctuation in the body’s temperature due to events such as increasing metabolism. Cholesterol binds to the hydrophobic tails of the lipid bilayer. When the temperature is low, the cholesterol molecules prevent the hydrophobic tails from compacting and solidifying. When the temperature is high, the hydrophobic tails will be excited and will move excessively. This excess movement will bring instability to the bilayer. Cholesterol will prevent excessive movement.

Which of the following hormones utilizes cholesterol as a precursor? 

I. Cortisol

II. Aldosterone

III. Mineralocorticoid 

Possible Answers:

I, II and III 

I only

III only

None of these

II only

Correct answer:

I, II and III 

Explanation:

Both cortisol and aldosterone are synthesized in the adrenal cortex with cholesterol as the precursor. Mineralocorticoid refers aldosterone, which is also secreted by the adrenal cortex. All of these hormones are steroidal, which means they are derived from cholesterol. Other steroid hormones are the sex hormones.  

Example Question #341 : Organic Chemistry, Biochemistry, And Metabolism

The body attempts to maintain a steady concentration of glucose in the blood, promoting consistent brain function and red blood cell survival. When glucose levels fall, however, the body breaks down glycogen to replenish stores for a short period of time before new glucose molecules are made through the process of gluconeogenesis.

In which organ does gluconeogenesis occur?

Possible Answers:

Heart

Brain

Liver

Skeletal muscle

Correct answer:

Liver

Explanation:

Gluconeogenesis, the process of creating new glucose from precursors, occurs in the liver and to a very small extent in the cortex of the kidney. The largest stores of glycogen are also located in the liver, but become quickly depleted in situations of low blood glucose.

Example Question #1 : Other Metabolic Pathways

The process of glycolysis is used by all cells of the body to turn glucose into ATP for cellular energy. When stores of glucose are low, however, the body can break down a form of stored glucose in the liver to increase glucose reserves.

What molecule is broken down by a phosphorylase in the liver to yield glucose-1-phosphate?

Possible Answers:

Glycogen

RNA

Triacylglycerol

Glycosylated protein

Correct answer:

Glycogen

Explanation:

Glycogen is the polymer form of glucose, stored in the liver and other tissues when glucose is abundant. When glucose levels are high, glucose-1-phosphate is assembled into branching chains of glycogen. When glucose levels fall, glycogen is broken down by glycogen phosphorylase back into glucose-1-phosphate units. These monomers can be used in glycolysis and cellular respiration. Glycogen is the first source of energy that is used when glucose stores are low.

Example Question #1 : Other Metabolic Pathways

Which of the following cannot be directly converted to acetyl-CoA?

Possible Answers:

Alpha-keto acid

Fatty acids

Glucose

Pyruvate

All of these answers can be directly converted to acetyl-CoA

Correct answer:

Glucose

Explanation:

Pyruvate can be converted to acetyl-CoA by decarboxylation. Beta oxidation can convert fatty acids to acetyl-CoA. Transaminases can be used to make alpha-keto acids, which can be converted to acetyl-coA. Glucose cannot be directly converted to acetyl-CoA; it must be transformed into pyruvate first.

Example Question #2 : Other Metabolic Pathways

Which of the following is not an adequate alternative energy source for humans?

Possible Answers:

Fatty acids

Triglycerides

Glycogen

Cellulose

Alpha-keto acids

Correct answer:

Cellulose

Explanation:

Carbohydrates can be stored as glycogen in the liver, fats can be stored as triglycerides or fatty acids in adipose tissue, and proteins can be made into alpha-keto acids. Hence, all of these are forms of energy storage that can be used as alternative energy sources.

Cellulose is a polysaccharide that is found in plants. Humans cannot digest cellulose due to its beta-glycosidic linkages.

Example Question #3 : Other Metabolic Pathways

When the body is unable to renew its glucose stores through glycogenolysis and gluconeogenesis, it makes ketone bodies derived from beta-oxidation of free fatty acids. Which of the following is not a ketone body utilized by the brain during periods of starvation?

Possible Answers:

Acetoacetate

Acetone

Aldehyde

Beta-hydroxybutyrate

Correct answer:

Aldehyde

Explanation:

The three ketone bodies utilized by the body are acetoacetate, beta-hydroxybutyrate, and acetone. These are produced from acetyl-CoA during beta-oxidation. Acetyl-CoA undergoes conversion reactions to the three ketone bodies in the liver.

Even if you did not know the names of the ketone bodies, you should know that aldehyde is not a ketone because its carbonyl moiety does not have carbons connected from both sides to the carbonyl carbon.

Learning Tools by Varsity Tutors