MCAT Biology : MCAT Biological Sciences

Study concepts, example questions & explanations for MCAT Biology

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Example Questions

Example Question #1392 : Biology

Human chromosomes are divided into two arms, a long q arm and a short p arm.  A karyotype is the organization of a human cell’s total genetic complement.  A typical karyotype is generated by ordering chromosome 1 to chromosome 23 in order of decreasing size. 

When viewing a karyotype, it can often become apparent that changes in chromosome number, arrangement, or structure are present.  Among the most common genetic changes are Robertsonian translocations, involving transposition of chromosomal material between long arms of certain chromosomes to form one derivative chromosome.  Chromosomes 14 and 21, for example, often undergo a Robertsonian translocation, as below.

1

A karyotype of this individual for chromosomes 14 and 21 would thus appear as follows:

Pic2

Though an individual with aberrations such as a Robertsonian translocation may be phenotypically normal, they can generate gametes through meiosis that have atypical organizations of chromosomes, resulting in recurrent fetal abnormalities or miscarriages.

 

The principal chemical component of chromosomes is nucleic acid, though proteins are also important elements. Which of the following is true of nucleic acids?

Possible Answers:

Ribosomes are important in the synthesis of RNA molecules

DNA contains uracil residues, while RNA contains thymine

Guanine-cytosine rich regions have higher melting points than adenine-thymine rich regions

RNA provides the main storage form of genetic information

DNA is translated directly by tRNA linked to amino acids

Correct answer:

Guanine-cytosine rich regions have higher melting points than adenine-thymine rich regions

Explanation:

Guanine-cytosine pairing forms three hydrogen bonds, instead of the two bonds formed by adenine and thymine. The other choices are all tempting, but subtly wrong. RNA contains uracil, DNA is the main storage form for information, mRNA is directly translated by tRNA, and ribosomes are important in the synthesis of proteins. It is worth noting that the 2' hydroxyl group of RNA's pentose sugar backbone is lost in DNA, which increases the stability and allows DNA to serve as a stable storage medium.

Example Question #1781 : Mcat Biological Sciences

Pick the reason that is least likely to explain why two purines will never be seen attached to each other in a DNA helix.

Possible Answers:

Two purines could cause a bump in the DNA, causing problems with transcription and replication.

Purine bases will never be found on opposite DNA strands, so they do not have the ability to pair with one another.

The bulky two-ring structure of purines would cause too much hindrance in the inside of the helix.

The functional groups at the end of one purine would not correctly match with the other purine. 

Correct answer:

Purine bases will never be found on opposite DNA strands, so they do not have the ability to pair with one another.

Explanation:

DNA strands are composed of millions of nucleotides. As a result, it would be virtually impossible to find a single strand that did not have all four nucleotides.

Nucleotides combine in purine-pyrimidine pairs due to the sterically appropriate fit of the bases, as well as the preferred combination of hydrogen bonds between the two nucleotides. As a result, two purines would not be seen combined. This is due to both being too large when together, and the incorrect hydrigen bonding between their functional groups.

Example Question #1782 : Mcat Biological Sciences

Which segment of DNA would have the highest melting point when paired with its complimentary strand?

Possible Answers:

5’ TTACTA 3’

5’ CGCTAT 3’

5’ CGTACG 3’

5’ TTCGAG 3’

5’ TGACAT 3’

Correct answer:

5’ CGTACG 3’

Explanation:

DNA nucleotide base pairs are held together by hydrogen bonding. Cytosine and guanine are held together by three hydrogen bonds, where adenine and thymine are held together by only two. Increased hydrogen bonding within a strand of DNA will increase the melting point. The DNA segment with the most guanine-cytosine base pairs will have the highest melting point.

Example Question #51 : Dna, Rna, And Proteins

Which of the following options include degenerate codons?

Possible Answers:

UCA: Serine

CAC: Histidine

GGG: Glycine

UAA: Stop

ATG: Methionine (start)

AUC: Isoleucine

UUU: Phenylalanine

ATG: Methionine (start)

CCU: Proline

UCU: Serine

UCA: Serine

AGA: Arginine

Correct answer:

UCU: Serine

UCA: Serine

AGA: Arginine

Explanation:

The term "degenerate codons" refers to codons with different nucleotide base sequences that specify the same amino acid. In the provided examples, two codons (UCU and UCA) both specify serine, indicating this is the correct answer.

Example Question #351 : Cell Biology, Molecular Biology, And Genetics

In 2013, scientists linked a cellular response called the unfolded protein response (UPR) to a series of neurodegenerative diseases, including such major health issues as Parkinson’s and Alzheimer’s Disease. According to their work, the unfolded protein response is a reduction in translation as a result of a series of enzymes that modify a translation initiation factor, eIF2, as below:

Untitled

In the above sequence, the unfolded protein sensor binds to unfolded protein, such as the pathogenic amyloid-beta found in the brains of Alzheimer’s Disease patients. This sensor then phosphorylates PERK, or protein kinase RNA-like endoplasmic reticulum kinase. This leads to downstream effects on eIF2, inhibition of which represses translation. It is thought that symptoms of neurodegenerative disease may be a result of this reduced translation.

During translation, the genetic code is used to convert a sequence of nitrogenous bases in mRNA to an amino acid sequence. Which of the following is true of the genetic code?

I.  More than one codon sequence codes for a single amino acid

II.  The most 5' position of the codon on mRNA is the wobble position

III.  Each codon sequence only codes for one amino acid

Possible Answers:

I and II

III, only

II and III

I and III

II, only

Correct answer:

I and III

Explanation:

The genetic code is unambiguous, because each codon only codes for one amino acid. It is also degenerate, so that each amino acid can be coded for by multiple codons. Choice 2 is incorrect, as the most 3' position on the mRNA is the wobble position.

Example Question #1783 : Mcat Biological Sciences

A short polynucleotide strand with the base sequence of AUCCCUGG must be __________.

Possible Answers:

mRNA

tRNA

It cannot be determined

rRNA

Correct answer:

It cannot be determined

Explanation:

Polynucleotide sequences are nucleic acids, so they must be DNA or RNA. Any sequence containing U (uracil) must be RNA, however there is no way to determine the type of RNA simply by looking at the sequence. This sequence could code for mRNA, rRNA, or tRNA.

mRNA is used to translate proteins. rRNA plays a structural and functional role in composing ribosomes. tRNA carries amino acids to the ribosome during translation.

Example Question #1784 : Mcat Biological Sciences

Which of the following correctly arranges the bases on the anti-codon loop of a tRNA carrying tryptophan?

Tryptophan codon: 3'-UGG-5'

Possible Answers:

3'-GGU-5'

3'-CCT-5'

3'-CCA-5'

3'-GUU-5'

3'-ACC-5'

Correct answer:

3'-CCA-5'

Explanation:

Tryptophan, which is encoded on mRNA as 3'-UGG-5', is going to be transported to the ribosome via tryptophan t-RNA. The anti-codon loop must be complementary to the mRNA strand. Since the code for Tryptophan is 3'-UGG-'5, the anti-codon loop of the t-RNA must read 3'-CCA-5' in order to line up.

mRNA: 3'-UGG-'5

tRNA: 5'-ACC-3'

Example Question #1785 : Mcat Biological Sciences

The codons GGU, GGA, GGC, and GGG all code for the same amino acid, glycine. What biological term is used to describe this phenomenon?

Possible Answers:

Codominance

Degeneracy

Polygenetic trait

Point mutation

X-chromosome inactivation

Correct answer:

Degeneracy

Explanation:

Degeneracy refers to the fact that more than one codon can code for the same amino acid. These codons generally differ in their third or "wobble" base. Degeneracy explains how there can be a total of sixty-four possible codons corresponding to only twenty amino acids.

Example Question #11 : Dna And Rna Sequencing

A sequence of DNA is written below.

5'-AGCCGTAAG-3'

 

What will be the squence of the strand created from this one by DNA polymerase during replication?

Possible Answers:

5'-CTTACGGCT-3'

5'-GAATGCCGA-3'

5'-TCGGCATTC-3'

5'-AGCCGTAAG-3'

Correct answer:

5'-CTTACGGCT-3'

Explanation:

Remember that DNA polymerase builds the new strand by reading the original DNA strand in a 3' to 5' direction. The newly formed strand will be read 5' to 3' and will have nucleotides that are complementary to the original strand.

Example Question #1401 : Biology

Which of the following will be the complimentary pairing of this coded gene during transcription?

3’ GCTAGC 5’

Possible Answers:

3’ CGAUCG 5’

5’ CGAUCG 3’

3’ CGATCG 5”

5’ CGATCG 3’

Correct answer:

5’ CGAUCG 3’

Explanation:

During transcription, a complimentary RNA strand is constructed from a DNA template. It is important to realize that in RNA, the nucleotide base uracil is used instead of thymine as a complementary pair with adenine. The complementary strand is constructed 5’ to 3’ , but is lined up anti-parallel to the original strand.

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