MCAT Biology : Systems Biology and Tissue Types

Study concepts, example questions & explanations for MCAT Biology

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Example Questions

Example Question #3 : Bone

Which of the following is true relating cartilage to the skeletal system?

Possible Answers:

Cartilage is produced via the breakdown of muscle and bone

Cartilage is not found in joints and vertebral discs

Cartilage has the ability to regenerate

Cartilage is an intermediate that is stiffer than muscle, but softer than bone

There are two types of cartilage

Correct answer:

Cartilage is an intermediate that is stiffer than muscle, but softer than bone

Explanation:

Cartilage is a flexible, avascular connective tissue. It is less flexible than muscle, but softer and more flexible than bone. These properties make it an ideal candidate for joints, providing a medium between the muscles and bones that enact forces on the joint. Cartilage is found on the epiphyses of long bones and between certain bones, such as vertebrae, to cushion the motion of the joints.

Due to its avascular nature, cartilage does not easily regenerate. It is formed by chondroblasts (cartilage cells) in a chondrin matrix. In endochondral ossification, cartilage can be used as a precursor to bone, but will never be formed as a result of bone breakdown. Finally, there are three types of cartilage: elastic cartilage, hyaline cartilage, and fibrous cartilage.

Example Question #3 : Bone

The diaphysis is able to grow in length because of thin layers of cartilage cells located in which of the following regions?

Possible Answers:

Periosteum

Medullary cavity

Marrow

Epiphyseal plate

Haversian canal

Correct answer:

Epiphyseal plate

Explanation:

Thin layers of cartilage cells in the epiphyseal plate enable the diaphysis (bone shaft) to grow in length. The epiphyseal line forms when growth stops and ossification occurs, permanently fusing the diaphysis and epiphysis.

The periosteum is a tough connective tissue sheath that covers the outer surface of bones. The medullary cavity is a hollow cylinder inside the diaphysis. The medullary cavity contains bone marrow, which contains blood cells in different stages of development. The Haversian canals perforate bony structure and contain blood vessels, lymph vessels, and nerves. 

Example Question #2 : Bone

What type of bone cell is responsible for resorbing bone tissue?

Possible Answers:

Cartilage

Osteoblasts

Osteoclasts

Lacunae

Osteocytes

Correct answer:

Osteoclasts

Explanation:

Osteoclasts are bone cells that are responsible for resorbing—or breaking down—bone tissue. Osteoblasts, on the other hand, deposit bone tissue.

Cartilage is not a type of bone cell at all; it is a type of connective tissue consisting of chondrocytes suspended in an avascular matrix. Lacunae are small cavities within the bone matrix that house osteocytes; osteocytes are mature bone cells.

Example Question #2 : Bone

How do bones maintain a functional weight as they grow?

Possible Answers:

Osteocytes form long fibers around the medullary cavity

Osteoclasts lining the medullary cavity remove interior layers of matrix

Osteocytes create new Haversian systems to limit the bone weight

Osteoblasts secrete acidic compounds, which dissolve some of the adjoining matrix

Osteoblasts creates new lacuna to surround bone cells

Correct answer:

Osteoclasts lining the medullary cavity remove interior layers of matrix

Explanation:

Osteoclasts dissolve bony matrix and repatriate calcium as the bone grows. This expands the meduallary cavity and maintains a manageable mass for the bones, while allowing the body to recycle valuable calcium deposits.

Example Question #1 : Bone Development And Growth

Where are osteocytes located?

Possible Answers:

The lining of the medullary cavity

Surrounding the growth plates

Beneath the periosteum

Throughout the hydroxyapatite matrix

The lacunae of Haversian systems

Correct answer:

The lacunae of Haversian systems

Explanation:

Osteoytes, the long-lived star-shaped cells found in established bones, are primarily found within Haversian systems—the target-shaped tubes of bone matrix. They are encased in a bubble of interstitial fluid known as a lacuna.

Example Question #3 : Bone

An adolescent girl is suffering from reduced longitudinal bone growth in her humerus. Which of the following bone regions should be examined closely in order to determine the cause of the growth deficiency?

Possible Answers:

Articular cartilage

The periosteum

The epiphyseal plate

The diaphysis

Correct answer:

The epiphyseal plate

Explanation:

Longitudinal bone growth occurs at the epiphyseal plate through the process of endochondral ossification. Cartilage cells undergo rapid mitosis in this region forming the structure that is later replaced by bone tissue.

Example Question #281 : Systems Biology And Tissue Types

In childbirth, the child’s skull is flexible due to fontanelles, or soft regions that are composed of connective tissue. Through what process does the connective tissue of the infant’s skull become bone?

Possible Answers:

Compact bone resorption

Endochondral ossification

Bony secretion

Intramembranous ossification

Correct answer:

Intramembranous ossification

Explanation:

Intramembranous ossification is the process in which bones are formed within dermal tissue. This process is responsible for forming the flat bones of the skull, as well as the clavicle. Other bones of the body are formed by the process of endochondral ossification, in which cartilage is replaced by bone tissue.

Example Question #1 : Types Of Bone Cells

__________ function to synthesize bone tissue and __________ function to reabsorb bone tissue.

Possible Answers:

Osteoclasts . . . osteoclasts

Osteoblasts . . . osteoclasts

Osteoclasts . . . osteoblasts

Osteoblasts . . . osteoblasts

Correct answer:

Osteoblasts . . . osteoclasts

Explanation:

Bones consist of two types of cells that regulate bone growth: osteoblasts and osteoclasts. Osteoblasts lay down collagen and other important organic substances that are required to synthesize bone tissue, whereas osteoclasts reabsorb existing bone tissue. The activity of both cells is important for repair, growth, and maintenance of bone tissue.

Note that a third type of cell, osteocytes, is also found in bone, but does not play as much of an active role in maintaining bone structure.

Example Question #1 : Types Of Bone Cells

Several tests reveal that a unknown hormone reverses the effects of parathyroid hormone. What can you conclude about this unknown hormone?

Possible Answers:

It decreases osteoblast activity and decreases blood calcium levels

It decreases osteoblast activity and increases blood calcium levels

It decreases osteoclast activity and increases blood calcium levels

It decreases osteoclast activity and decreases blood calcium levels

Correct answer:

It decreases osteoclast activity and decreases blood calcium levels

Explanation:

The question states that the unknown hormone has the opposite effect of parathyroid hormone. Recall that parathyroid hormone functions to increase blood calcium levels; therefore, this unknown hormone must decrease blood calcium levels.

When blood calcium levels increase due to parathyroid hormone, osteoclasts in bones break down the bone matrix and release the calcium into the blood. This means the activity of the unknown hormone must inhibit the activity of osteoclasts to decrease blood calcium levels. This hormone is most likely released to prevent bone loss.

The unknown hormone in this question would most likely be calcitonin. Calcitonin decreases blood calcium levels and is very important in menopausal and pregnant women who have a higher risk of having excessive bone loss.

Example Question #2 : Types Of Bone Cells

A researcher takes a sample of bone tissue and observes a cell under a microscope. He notices that the cell is in the process of breaking down its nuclear membrane. Based on this information, what can the researcher conclude about this cell?

Possible Answers:

The cell is an osteoclast

The cell can be either an osteoblast or an osteoclast

The cell cannot be an osteoblast or an osteoclast

The cell is an osteoblast

Correct answer:

The cell cannot be an osteoblast or an osteoclast

Explanation:

The question states that the cell is breaking down its nuclear membrane. Recall that the nuclear membrane is broken down during prophase of mitosis or prophase I of meiosis; therefore, the cell must be undergoing either mitosis or meiosis. One of the key characteristics of osteoblasts, osteocytes, and osteoclasts is that they do not undergo mitosis. Also, remember that only germ cells undergo meiosis. Since the observed cell is undergoing a division, the researcher can conclude that the cell is not an osteoblast or an osteoclast.

Osteogenic cells, however, can undergo mitosis. Osteogenic cells are cells that differentiate into osteoblasts. Once differentiated, the osteogenic cells can no longer undergo mitosis.

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