GRE Subject Test: Biochemistry, Cell, and Molecular Biology : Help with Protein Transport
Study concepts, example questions & explanations for GRE Subject Test: Biochemistry, Cell, and Molecular Biology
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Example Questions
Example Question #1 : Help With Protein Transport
Which of the following does not require a post-translational modification of a protein to be properly targeted to its destination?
I. Nuclear localization
II. Targeting proteins to the lysosome
III. Targeting proteins to the proteasome
IV. Nuclear export
I only
II and III
I and IV
I, II, and IV
I and IV
Nuclear import and export do not require post-translational modifications. The nuclear localization sequence or the nuclear export sequence is contained within the amino acid sequence itself (primary structure), and does not require and special modification.
For targeting to the proteasome, proteins must be ubiquinated. To target a protein to the lysosome the addition of a mannose-6-phosphate is commonly made.
Example Question #2 : Protein Regulation
Which of the following organelles would be least important in a cell that creates and secretes proteins?
Smooth endoplasmic reticulum
Ribosomes
Rough endoplasmic reticulum
Golgi apparatus
Smooth endoplasmic reticulum
When considering a protein creating/secreting cell, the organelles that are responsible for packaging and secreting the proteins will be most important. Starting at the beginning, proteins will be translated using the ribosomes found on the rough endoplasmic reticulum. Those will then be sent to the golgi apparatus for proper packaging. Those packages will then be released from the cell. The smooth endoplasmic reticulum will not be a vital organelle for protein creation and secretion.
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All GRE Subject Test: Biochemistry, Cell, and Molecular Biology Resources
