Biochemistry : Protein Catabolism

Study concepts, example questions & explanations for Biochemistry

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Example Questions

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Example Question #2 : Other Protein Catabolism Concepts

During the urea cycle, which enzyme catalyzes the rate-limiting step in the mitochondria?

Possible Answers:

Phosphofructokinase (PFK)

Triose phosphate isomerase

Citrate synthase

Glucose-6-phosphate dehydrogenase 

Carbamoyl phosphate synthase

Correct answer:

Carbamoyl phosphate synthase

Explanation:

Triose phosphate isomerase catalyzes the isomerization between dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. Glucose-6-phosphate dehydrogenase is a regulatory enzyme for the pentose phosphate pathway. Citrate synthase is a regulatory enzyme for the Krebs cycle, catalyzing the synthesis of citrate from acetyl-CoA and oxaloacetate. PFK catalyzes the rate-limiting step in glycolysis.

Example Question #3 : Other Protein Catabolism Concepts

What is the difference between ketogenic and glucogenic amino acids?

I. Ketogenic amino acids are degraded to acetyl-CoA and ketones; glucogenic amino acids can be converted to glucose

II. Ketogenic amino acids are alanine and glutamine

III. The ketogenic amino acids are leucine and lysine

IV. Amino acids that are glucogenic and ketogenic are: phenylalanine, tyrosine, tryptophan, isoleucine and threonine

Possible Answers:

I and IV

II and III

III and IV

I, III, and IV

I, II, III, and IV

Correct answer:

I, III, and IV

Explanation:

Ketogenic amino acids are degraded to Acetyl Coenzyme A (CoA) and ketones; glucogenic amino acids can be converted to glucose. Amino acids that are both ketogenic and glucogenic can be metabolized to both glucose and ketone bodies. Purely ketogenic aminoacids are leucine and lysine. Amino acids that are glucogenic and ketogenic are: phenylalanine, tyrosine, tryptophan, isoleucine and threonine. All the other amino acids are glucogenic.

Example Question #4 : Other Protein Catabolism Concepts

All of the following are intermediate molecules in the urea cycle except __________.

Possible Answers:

ornithine

citrulline

arginosuccinate

citrate

arginine

Correct answer:

citrate

Explanation:

In the urea cycle, carbomyl phosphate first combines with the molecule ornithine. This forms citrulline. Citrulline then reacts with aspartate to form arginosuccinate. Fumarate dissociates from arginosuccinate forming arginine, and then the addition of water forms urea and ornithine once again to complete the cycle. Citrate is not involved in this cycle, it is however in the Krebs cycle.

Example Question #749 : Biochemistry

Carbomyl phosphate is a molecule that can enter into the urea cycle. It is formed from the coupling of what two molecules?

Possible Answers:

 and 

 and 

 and

 and 

 and 

Correct answer:

 and

Explanation:

Free  and bicarbonate  can come together to form carbomyl phosphate which can then enter into the urea cycle.

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