Biochemistry : Anabolic Pathways and Synthesis

Study concepts, example questions & explanations for Biochemistry

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Example Questions

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Example Question #1 : Carbohydrate Anabolism

What is the major distinction between NADH and NADPH in biochemistry?

Possible Answers:

NADH is oxidized in catabolic reactions to produce ATP, wheres NADPH serves as a reducing agent in anabolic reactions

NADH is used in reactions to create ATP, whereas NADPH is used in reactions to produce ADP

NADH is used primarily by eukaryotes, whereas NADPH is used primarily by prokaryotes

NADPH is oxidized in catabolic reactions to produce ATP, wheres NADH serves as a reducing agent in anabolic reactions

NADH and NADPH serve the same function in all reactions

Correct answer:

NADH is oxidized in catabolic reactions to produce ATP, wheres NADPH serves as a reducing agent in anabolic reactions

Explanation:

The major distinction between NADH and NADPH is that NADH is generally used in catabolic reactions meant to produce ATP.  NADPH, on the other hand, is used primarily in anabolic reactions meant to build macromolecules from their smaller parts.

Example Question #1261 : Biochemistry

What is the role of phosphoenolpyruvate carboxykinase in carbohydrate metabolism?

Possible Answers:

Carbon dioxide is a byproduct of the reaction that it catalyzes

Guanosine triphosphate (GTP) is converted to guanosine diphosphate (GDP) by the enzyme

All of these

The enzyme converts oxaloacetate to phosphophenolpyruvate

The reaction catalyzed by this enzyme is one of the first steps in gluconeogenesis

Correct answer:

All of these

Explanation:

Gluconeogenesis is the production of glucose from other sources than carbohydrates, such as  from pyruvate, amino acids, lactate and glycerol. Phosphoenolpyruvate carboxykinase converts oxaloacetate to phosphoenolpyruvate and carbon dioxide. It also produces GDP from GTP. It is regulated by hormones, such as glucagon and cortisol.

Example Question #11 : Carbohydrate Anabolism

What two molecules are the links between the urea cycle and gluconeogenesis?

Possible Answers:

Oxaloacetate and citrate

Fumarate and aspartate

Citrate and aspartate

Fumarate and citrate

Oxaloacetate and fumarate

Correct answer:

Fumarate and aspartate

Explanation:

Aspartate can form arginosuccinate, which can then release a fumarate molecule. The fumarate can enter into the Krebs cycle and eventually the pathway can lead to gluconeogenesis. The arginine from the arginosuccinate can continue through the urea cycle.

Example Question #132 : Anabolic Pathways And Synthesis

In order to be added to a growing glycogen chain, glucose must first be activated by which of the following molecules?

Possible Answers:

UTP

GDP

ADP

ATP

UDP

Correct answer:

UDP

Explanation:

UDP-glucose is the activated form of glucose that works to build chains of glycogen. The other listed molecules do not serve this function.

Example Question #12 : Carbohydrate Anabolism

How does ingestion of high amounts of ethanol affect gluconeogenesis?

I. High amounts of ethanol get oxidized producing NADPH.

II. High levels of NADPH inhibit gluconeogenesis. 

III. High levels of NADPH stimulate gluconeogenesis.

IV. High amounts of ethanol get oxidized producing NADP.

Possible Answers:

I and IV

I and II 

III only

II and IV

I and III

Correct answer:

I and II 

Explanation:

Ingestion of high amounts of ethanol leads to increased NADPH. High levels of NADPH inhibit gluconeogenesis followed by low glucose levels in the absence of dietary intake. In acute ingestion of alcohol, hypoglycemia (low levels of glucose in the blood) can follow due to inhibition of gluconeogenesis.

Example Question #134 : Anabolic Pathways And Synthesis

What is the net yield from the pentose phosphate pathway?

I. 

II. 

III. 

IV. 

Possible Answers:

I only

 I and II

 IV only

 II only

 III only

Correct answer:

I only

Explanation:

The pentose phosphate pathway produces NADPH and five-carbon sugars. The net reaction is:

The pathway is also important in purine precursor synthesis.

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