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Example Questions
Example Question #22 : Musculoskeletal System And Muscle Tissue
Tests reveal that a certain patient has depleted calcium stores in his sarcoplasmic reticulum. Which of the following is a direct consequence of this abnormality?
Troponin cannot remove tropomyosin from the active site on actin
Tropomyosin cannot remove troponin from the active site on actin
Troponin cannot remove tropomyosin from the active site on myosin
Tropomyosin cannot remove troponin from the active site on myosin
Troponin cannot remove tropomyosin from the active site on actin
In a typical muscle cell, tropomyosin is bound to an active site on actin. This prevents muscle contraction because the myosin head cannot bind to actin active site. Muscle contraction is initiated when the sarcoplasmic reticulum releases calcium ions into the cytoplasm of the muscle cell. Calcium ions bind to and activate troponin. Activated troponin molecules subsequently remove tropomyosin from the active site on actin. This allows muscle contraction to occur because the myosin head can now bind to the active site on actin and initiate a power stroke to shorten the sarcomere.
An individual with depleted calcium ions in his sarcoplasmic reticulum will not activate troponin and, therefore, will have reduced muscle tone and strength.
Example Question #221 : Biology
What is the role of the sarcoplasmic reticulum prior to a muscle contraction?
It creates the proteins needed to cover the actin filaments
It releases calcium once an action potential reaches the sarcolemma
It actively pumps calcium ions into its lumen
It releases calcium ions by active transport
It releases calcium once an action potential reaches the sarcolemma
The sarcoplasmic reticulum is responsible for the storage of calcium ions that are used in muscle contraction. Prior to a contraction, an action potential will reach the sarcoplasmic reticulum, making it permeable to calcium ions. At the end of the contraction, the sarcoplasmic reticulum will actively pump calcium ions back into its lumen.
The sarcoplasmic reticulum is not involved in protein synthesis.
Example Question #222 : Biology
The sarcoplasmic reticulum has the ability to aid in muscle contraction by storing large amounts of which ion?
Calcium plays a huge role in the regulation of muscle contraction. Without the presence of calcium, the myosin binding sites on the actin filaments are blocked by tropomyosin and muscle contraction cannot occur. Stimulation from the nervous system causes a chain reaction that releases large stores of calcium from the sarcoplasmic reticulum to regulate muscle contraction.
Sodium ions play an essential role in initiating the chain reaction that eventually leads to calcium release, but is not stored in the sarcoplasmic reticulum. Potassium plays a role in regulating membrane potential, but also is not stored in the sarcoplasmic reticulum. Protons are essential to mitochondrial function and play a crucial role in myocyte metabolism, but are not linked to the sarcoplasmic reticulum or contractile function.
Example Question #231 : Biology
The sarcoplasmic reticulum is a special type of endoplasmic reticulum. Based on this information, which of the following is associated with a sarcoplasmic reticulum?
I. Network of tubules
II. Digestive enzymes
III. Vesicles
I and III
II only
I only
I, II, and III
I and III
The question states that the sarcoplasmic reticulum is a specialized endoplasmic reticulum. This means that the structures that make up the sarcoplasmic reticulum must be similar to the endoplasmic reticulum. Recall that both endoplasmic reticulum (rough and smooth) are made up of a network of tubules. Similarly, both structures contain vesicles that transport processed molecules to a target location (proteins in rough endoplasmic reticulum and lipids in smooth endoplasmic reticulum); therefore, the sarcoplasmic reticulum must contain vesicles and a network of tubules.
The sarcoplasmic reticulum does not contain digestive enzymes, nor does the endoplasmic reticulum. Digestive enzymes are usually found in degradative organelles, such as lysosomes.
Example Question #232 : Biology
A person has a mutation that produces abnormal sarcoplasmic reticulum. Which of the following will not be a consequence of this mutation?
Troponin will not be activated
Calcium ions will not be released into a synapse, and propagation of action potentials will stop
The myosin heads will not bind the actin filaments
Tropomyosin will remain bound to actin
Calcium ions will not be released into a synapse, and propagation of action potentials will stop
The main function of the sarcoplasmic reticulum is to store and release calcium ions. Calcium ions released into the cytoplasm of a muscle cell activate troponin. Activated troponin removes tropomyosin from actin, which opens up the myosin active site on actin. Myosin head binds to actin, which causes muscle contraction.
The sarcoplasmic reticulum does not play a role in releasing calcium ions into synapses during action potential propagation. The calcium ions in synapses are released via vesicles in the presynaptic neuron; therefore, an abnormal sarcoplasmic reticulum will not stop the release of calcium ions in neuronal synapses.
Example Question #231 : Biology
Which of the following is false about the sarcoplasmic reticulum?
The sarcoplasmic reticulum is a specialized smooth endoplasmic reticulum
The sarcoplasmic reticulum is found only in voluntary muscle cells
A change in membrane potential causes the sarcoplasmic reticulum to become more permeable to calcium ions
The sarcoplasmic reticulum releases calcium ions into the cytoplasm of the muscle cell
The sarcoplasmic reticulum is found only in voluntary muscle cells
The sarcoplasmic reticulum is an organelle that closely resembles the smooth endoplasmic reticulum. They are structurally similar, but have very different functions. The main function of the sarcoplasmic reticulum is to store and release calcium, whereas the smooth endoplasmic reticulum functions in lipid synthesis.
Muscle contraction is usually initiated by an action potential. The first step in muscle contraction is the release of calcium ions from the sarcoplasmic reticulum; therefore, a change in membrane potential (action potential) will stimulate the sarcoplasmic reticulum to become more permeable to calcium ions. Once stimulated, the sarcoplasmic reticulum releases calcium ions into the cytoplasm, where the calcium ions interact with troponin and remove tropomyosin from actin. This sequence allows for myosin to bind actin and shorten the sarcomere, resulting in contraction.
The sarcoplasmic reticulum is actually found in all three types of muscle cells: smooth muscle, cardiac muscle, and skeletal muscle. Recall that skeletal muscles are voluntary, whereas smooth and cardiac muscles are involuntary; therefore, sarcoplasmic reticulum is found in both voluntary and involuntary muscles.
Example Question #251 : Mcat Biological Sciences
Binding of myosin head to actin generates muscle contraction. After muscle contraction the myosin head has to be removed from the actin. Which of the following accomplishes this task?
Binding of ATP to tropomyosin
Binding of calcium to troponin
Binding of ATP to myosin head
Binding of troponin to actin
Binding of ATP to myosin head
Remember that troponin, tropomyosin, and calcium are not involved in the detachment of myosin head from actin; they are involved in the attachment of myosin head to actin. The molecule required for muscle relaxation (detachment of myosin head from actin) is ATP. After muscle contraction, a molecule of ATP binds to the myosin head and signals it to detach from the active site on actin. After detachment, myosin head converts the ATP to ADP and inorganic phosphate and the cycle of muscle contraction and muscle relaxation continues.
Example Question #233 : Biology
The contraction of muscle by actin and myosin is described by which biological theory?
Endosymbiotic theory
Central Dogma theory
Sliding filament theory
Cross-bridge theory
Sliding filament theory
The theory that describes the movement of actin and myosin is the sliding filament theory. This theory proposes that the myosin filaments slide relative to the actin filaments and shorten the length of sarcomere. A sarcomere is the basic unit of muscle; therefore, when myosin filaments shorten the length of the sarcomere, the muscle contracts.
Cross-bridge theory is not an actual theory. A cross-bridge is a term used to describe the linkage between actin and myosin. Endosymbiotic theory states that mitochondria and chloroplasts were originally prokaryotes that evolved by forming a symbiotic relationship with eukaryotic cells. This explains why mitochondria and chloroplasts have their own unique DNA. Finally, the Central Dogma theory describes the flow of genetic information in a living organism. It states that genetic information is transferred through the processes of replication, transcription, and translation.
Example Question #11 : Muscle Stimulation And Contraction
A muscle will not have all of its fibers contract at once. Instead, the muscle is divided into multiple bundles of muscle fibers, with a neuron innervating all of the fibers in a given bundle. Each collection of fibers controlled by a single neuron is referred to as a motor unit.
Which of the following statements is false when discussing motor units?
The neuron will create an action potential in the muscle by releasing acetylcholine into the synaptic cleft.
When lifting an object, motor units are recruited as needed in order to provide a smooth, controlled motion.
Muscles requiring finer, more precise motions are composed of smaller motor units.
Larger motor units are typically activated first in order to provide immediate stability.
Larger motor units are typically activated first in order to provide immediate stability.
Smaller motor units are activated first during muscular contraction. If more force is needed, larger motor units will be recruited in order to provide the necessary force.
Example Question #33 : Musculoskeletal System And Muscle Tissue
Skeletal muscle fibers are not all contracted at once by the same action potential. Instead, muscle fibers are divided into clusters that can range from two to two thousand cells. All of these muscle fibers are innervated by the same neuron; the muscle fibers and the neuron that innervates them are collectively referred to as a motor unit.
Which of the following statements is true concerning motor units?
Motor unit neurons only transmit one action potential during a contraction
Large motor units are innervated first in a muscle, followed by smaller units in order to have a smooth contraction
The neuron releases epinephrine across the synaptic cleft in order to stimulate an action potential in the sarcolemma
Finger muscles are typically composed of smaller motor units
Finger muscles are typically composed of smaller motor units
During a contraction, smaller motor units are typically fired first, followed by larger units in order to have a smooth, controlled movement. Movements that require fine, controlled motion, such as the muscles of the fingers, will be composed of smaller motor units.
The neurotransmitter associated with skeletal muscle is acetylcholine, not epinephrine. A single action potential may initiate contraction of a motor unit, but the neuron must continue to fire in order to sustain the contraction.
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