MCAT Biology : Hemoglobin, Blood Cells, and Blood Proteins

Study concepts, example questions & explanations for MCAT Biology

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Example Questions

Example Question #83 : Circulatory System

What could the blood pH of a person who has blood acidosis (more acidic blood than normal) possibly be?

Possible Answers:

7.2

Either 7.5 or 7.2

6.8

7.5

Either 7.2 or 6.8

Correct answer:

Either 7.2 or 6.8

Explanation:

The normal pH of blood is around 7.3, which means blood is normally slightly basic. A truly neutral pH is 7.0. Whenever the pH of blood is under 7.3 (not 7.0) it is considered acidosis, and so our answer is either 7.2 or 6.8.

Example Question #84 : Circulatory System

Which statement regarding blood typing is correct?

Possible Answers:

A person with O- blood can receive a blood donation from someone with O+ blood.

A person with AB- blood can donate to a person whose blood type is O-.

The presence of the Rh factor is coded for by a recessive allele.

A woman with Rh- blood is at risk for developing erythroblastosis fetalis during her first pregnancy if the fetus is Rh+.

A person with B- blood can donate to a person whose blood type is AB+.

Correct answer:

A person with B- blood can donate to a person whose blood type is AB+.

Explanation:

The AB+ blood type is known as the "universal recipient" type, therefore, people with any blood type can donate to an AB+ individual.

As for the incorrect answers, a person with O- blood has the "universal donor" type, and can only receive blood from other O- individuals. Erythroblastosis fetalis, also known as hemolytic disease of the newborn, cannot occur during a woman's first pregnancy because her body has not yet produced anti-Rh antibodies. Finally, Rh factor presence is a genetically dominant condition.

Example Question #21 : Hemoglobin, Blood Cells, And Blood Proteins

Which of the following accurately represents the entire composition of blood?

Possible Answers:

Erythrocytes, leukocytes, platelets

Serum, erythrocytes, leukocytes, platelets

Serum, plasma, erythrocytes, leukocytes, platelets

Plasma, erythrocytes, leukocytes, platelets

Correct answer:

Plasma, erythrocytes, leukocytes, platelets

Explanation:

Human blood contains 55% plasma and 45% cells. The cells include erythrocytes (red blood cells), leukocytes (white blood cells), and thrombocytes (platelets). Plasma is largely composed of water, protein (albumin), and clotting factors.

Note that blood serum is simply blood plasma with the clotting factor elements (fibrinogen) removed.

Example Question #21 : Hemoglobin, Blood Cells, And Blood Proteins

Which of the following most accurately depicts the process of clotting?

Possible Answers:

Thromboplastin is released and converts prothrombin to thrombin. Thrombin converts fibrinogen to fibrin, which recruits elements of the blood to form a clot.

Prothrombin is released and activates thrombin. Thrombin converts fibrinogen to fibrin, which stimulates the secretion of thromboplastin. Thromboplastin recruits elements of the blood to form a clot.

Thromboplastin is released and converts fibrinogen to fibrin, which recruits elements of the blood to form a clot.

Thromboplastin aggregates platelets to form a clot; fibrin and fibrinogen are structural elements of cells that are not related to clotting

Correct answer:

Thromboplastin is released and converts prothrombin to thrombin. Thrombin converts fibrinogen to fibrin, which recruits elements of the blood to form a clot.

Explanation:

Thromboplastin is released when damage occurs to a tissue. Prothrombin and fibrinogen are both present in the blood. When thromboplastin interacts with the blood, it converts prothrombin to its active state, thrombin. Thrombin then cleaves fibrinogen, converting it to its active state, fibrin. Fibrin is exceptional at forming cross-linked mesh-like interactions, and in doing so traps passing blood cells and plasma proteins. This blockage and accumulation of blood elements becomes the clot.

Example Question #22 : Hemoglobin, Blood Cells, And Blood Proteins

Albumin is created in the liver and is an important protein found in the blood. If a vial of blood is centrifuged, in which of the following layers would albumin be found?

Possible Answers:

The red blood cell layer

The buffy coat layer

The plasma layer

The leukocyte layer

Correct answer:

The plasma layer

Explanation:

When centrifuged, blood will divide into three parts: the plasma layer, the buffy coat layer, and the red blood cell layer. The plasma layer contains albumin, immunoglobulins, and blood clotting factors. The buffy coat is composed of leukocytes, and the red blood cell layer is composed of erythrocytes.

Example Question #23 : Hemoglobin, Blood Cells, And Blood Proteins

Which of the following is known as "bad cholesterol"?

Possible Answers:

Low-density lipoprotein cholesterol

High-density lipoprotein cholesterol

High-density lipoprotein and Low-density lipoprotein cholesterol

Total cholesterol

Correct answer:

Low-density lipoprotein cholesterol

Explanation:

Low-density lipoprotein (LDL) cholesterol are considered to be "bad cholesterol" because it transports fat molecules to arteries and attracts macrophages, leading to atherosclerosis. Alternatively, high-density lipoprotein (HDL) cholesterol is considered to be "good cholesterol" because it removes fat molecules from macrophages, decreasing the risk of atherosclerosis.

Example Question #24 : Hemoglobin, Blood Cells, And Blood Proteins

Coagulation factor II, also called prothrombin, plays an important role in the clotting process. A very rare genetic mutation causes a deficiency of coagulation factor II, resulting in a form of hemophilia due to a mutation affecting a protein produced by which organ?

Possible Answers:

Spleen

Heart

Lungs

Liver

Correct answer:

Liver

Explanation:

Coagulation Factor II (prothrombin) is a protein produced in the liver. Prothrombin is modified after translation to produce thrombin. Thrombin is an enzyme that catalyzes coagulation reactions and results in reduced blood loss. Factor II deficiency is an autosomal recessive mutation that can result in defects in blood clotting.

Example Question #25 : Hemoglobin, Blood Cells, And Blood Proteins

Type 1 diabetes is a well-understood autoimmune disease. Autoimmune diseases result from an immune system-mediated attack on one’s own body tissues. In normal development, an organ called the thymus introduces immune cells to the body’s normal proteins. This process is called negative selection, as those immune cells that recognize normal proteins are deleted. If cells evade this process, those that recognize normal proteins enter into circulation, where they can attack body tissues. The thymus is also important for activating T-cells that recognize foreign proteins.

As the figure below shows, immune cells typically originate in the bone marrow. Some immune cells, called T-cells, then go to the thymus for negative selection. Those that survive negative selection, enter into general circulation to fight infection. Other cells, called B-cells, directly enter general circulation from the bone marrow. It is a breakdown in this carefully orchestrated process that leads to autoimmune disease, such as type 1 diabetes.

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A doctor is studying blood collected from a sick patient. She centrifuges the blood sample to separate the hematocrit, the buffy coat, and the plasma. In which layer is she most likely to find most of the immune system cells?

Possible Answers:

Only in the buffy coat

Only in the hematocrit

In both the hematocrit and the plasma

In both the hematocrit and the buffy coat

Only in the plasma

Correct answer:

Only in the buffy coat

Explanation:

The buffy coat is so-named because it has the majority of white (immune) cellular material, while the hematocrit contains most of the red cell material (hemoglobin), and the plasma has the fluid and circulating proteins, such as antibodies.

Erythrocytes are found in the hematocrit, lymphocytes are found in the buffy coat, and clotting factors, albumin, and fluids are found in the plasma.

Example Question #26 : Hemoglobin, Blood Cells, And Blood Proteins

Which protein constitutes the largest percentage of plasma proteins and is responsible for transporting non-soluble substances through the body?

Possible Answers:

Thrombin

Albumin

Thromboxane

Plasminogen

Correct answer:

Albumin

Explanation:

Albumin is the protein that is involved in transporting a variety of products throughout the blood as well as the protein factors involved in blood clotting. Albumin makes up about 50% of the plasma protein distribution. It is responsible for binding insoluble molecules to transport them through the aqueous blood stream. Albumin is also the main driver of oncotic pressure in the arteries and veins to keep water from moving to the tissues via osmosis.

Plasminogen, thrombin, and thromboxane are all proteins involved in the clotting process and are also found in the blood.

Example Question #911 : Systems Biology And Tissue Types

An individual with hemophilia, most likely has a deficiency in which of the following proteins?

Possible Answers:

Albumin

Fibrinogen

Major histocompatibility complex proteins

Renin

Vasopressin

Correct answer:

Fibrinogen

Explanation:

Fibrinogen is converted to fibrin by the action of thrombin, and fibrin is the protein that actually forms a blood clot. An inability to properly form clots, such as is seen in hemophilia, could arise from a defect in fibrinogen, resulting in a problem with the clotting pathway.

Renin is an enzyme released by the kidney, which creates angiotensin to help raise blood pressure. Vasopressin is a posterior pituitary hormone that acts on the kidney to retain water. Albumin is a plasma protein that functions to maintain the oncotic pressure in the blood, as well as to transport fatty acids. Major histocompatibility complex (MHC) proteins are used to present antigens to the immune system.

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