Melatonin is the hormone secreted by the pineal gland, it controls the circardian rhythm and is responsible for feeling sleepy. Corticotropin, released by the adrenal cortex is associated with cortisol release. Insulin is the most notable hormone associated with glucose metabolism and is released by the pancreas. Gastrin, cholecystokinin, and secretin assist digestion. 

The sympathetic nervous system is one of two divisions of the autonomic nervous system; it is responsible for the "fight or flight" response and is involved in homeostasis. Some sympathetic fibers pass through the paravertebral ganglia of the sympathetic trunk, while other sympathetic fibers synapse there.

Parasympathetic nerves are associated with cranial nerves, and the dilation of blood vessels in skin of the back and limbs (the sympathetic system constricts these vessels). Preganglionic neurons originate in the thoracolumbar region of the spinal cord (T2 to L1) then travel to a paravertebral ganglion or prevertebral ganglion, where they synapse with a postganglionic neruon. The paravertebral ganglion are found throughout the length of the spinal cord, including the cervical, thoracic, lumbar, and sacral areas. 

The sympathetic nervous system is typically associated with "fight or flight" responses in the body. When you think of stressful situations, it helps to think of adrenaline (or epinephrine) being used by the body. The postganglionic neurons of the sympathetic nervous system will release the neurotransmitter epinephrine or norepinephrine, which will then attach to adrenergic receptors on the effector organ to initiate the sympathetic action.

The neurons of the parasympathetic nervous system and the preganglionic neurons of the sympathetic nervous system use acetylcholine.

Norepinephrine is the neurotransmitter that is released by the postganglionic neuron, and stimulates sympathetic responses in effectors. Acetylcholine is the primary neurotransmitter in post ganglionic neurons in the parasympathetic nervous system. Dopamine, GABA, and glycine are other transmitters used by the nervous system, but are not the primary neurotransmitter of the postganglionic sympathetic neurons.

As one moves from the transverse colon to the descending colon, the sympathetic innervation changes from the thoracic splanchnics to the lumbar splanchnics.

Pelvic splanchnic nerves provide parasympathetic innervation of pelvic and genital organs, including the distal third of the transverse colon, the descending colon, the sigmoid colon, and the rectum rectum. The proximal two thirds of the transverse colon, and the rest of the proximal gastrointestinal tract receives parasympathetic innervation from the vagus nerve.

The superior mesenteric, inferior mesenteric, and iliac arteries provide blood supply for the large intestine. The celiac trunk does not provide blood supply to the large intestine. Branches of the superior mesenteric artery mainly perfuse the transverse colon, while branches of the inferior mesenteric artery mainly perfuse the descending colon. Venous drainage mirrors colonic arterial supply, with both the superior and inferior mesenteric veins joining the hepatic portal vein. 

Cell bodies of preganglionic neurons are located in the central nervous system (CNS); they synapse onto autonomic ganglia. Parasympathetic ganglia are located in or near the effector organs giving them long preganglionic fibers and short postganglionic fiber. Sympathetic ganglia are located in the paravertebral chain, thus they have short preganglionic fibers and long postganglionic fibers.

The parasympathetic nervous system acts oppositely to the sympathetic nervous system, by signaling the activation of relaxation and digestion (increased blood flow to digestive system, pupil constriction, lower heart rate and blood pressure). The parasympathetic nervous system signal is transmitted to the body through a preganglionic neuron and a postganglionic neuron. Both of these use acetylcholine in the parasympathetic nervous system.

The autonomic nervous system can be divided into the sympathetic and parasympathetic nervous systems. Although both divisions have target organs and tissues, the parasympathetic postganglionic neurons are usually much closer to the effector organ than sympathetic postganglionic neurons.

The autonomic nervous system is under involuntary control, while the somatic nervous system is under voluntary control. Only sympathetic postganglionic neurons use epinephrine; most autonomic neurons use acetylcholine. Both divisions include neurons that originate from the spinal cord. The cranial nerves have both sensory and motor functions, meaning that they can be involved in either somatic or autonomic innervation.

The cranial nerves that are part of the visceral efferent parasympathetic in the PNS are III, VII, IX, and X. Cranial nerve III (oculomotor) travels to the ciliary ganglion and supplies the pupil of the eye for constriction. Cranial nerve VII (facial) travels to the pterygomandibular and submandibular ganglion and supplies the lacrimal and salivary glands. Cranial nerve IX (glossopharyngeal) travels to the otic ganglion and supplies the Parotid gland. Lastly, cranial nerve X (vagus) travels to the Prevertebral plexus and thoracic plexus in order to supply the gut, heart, and enteric system.

The pupillary sphincter muscles contain muscarinic cholinergic receptors that help the eyes to respond to parasympathetic tone. When this parasympathetic signal is blocked (antagonized) via atropine, you will observe a "sympathetic response" at the level of the pupil. In this scenario, you would observe the sympathetic response of pupil dilation. Hint: "aTROP'ine" and "seeing a TROPical setting" both cause your pupils to dilate nice and wide!