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Example Questions
Example Question #161 : Macromolecule Structures And Functions
A steroid molecule consists of how many fused carbon rings?
6
4
5
2
3
4
Steroids are derivatives of the molecule cyclopentanoperhydrophenanthrene which is composed of 4 fused carbon rings. There are three hexane rings and one pentane ring in the structure of steroids.
Example Question #1 : Sterols And Steroids
Cholesterol has a structure most similar to which of these?
Carbohydrate
Glycolipid
Steroid
Free fatty acid
Phospholipid
Steroid
Although it is one of the three main types of membrane lipids (along with phospholipids and glycolipids) cholesterol's structure is quite different. It is a steroid, and so it is made from four linked hydrocarbon rings, including three six-membered rings and one five-membered ring.
Example Question #2 : Sterols And Steroids
Which of the following is not made from cholesterol?
Progesterone
Cortisol
Estrodiol
Insulin
Testosterone
Insulin
Cholesterol is a very important molecule for a number of reasons. One function of cholesterol is to regulate membrane fluidity in the plasma membrane. Another very important role that cholesterol plays is as the precursor to a number of steroid hormones including cortisol, testosterone, estradiol, and progesterone. Insulin, however, is a peptide hormone made in the pancreas.
Example Question #3 : Sterols And Steroids
All of the carbons in cholesterol are derived from carbons in what molecule?
Glycerol
Glucose
Acetyl-CoA
Acetoacetate
Mevalonate
Acetyl-CoA
Cholesterol is a molecule with 27 carbon atoms. In order to synthesize this steroid, a three step process must be completed. First, isopentenyl pyrophosphate is synthesized. Second, six isopentenyl pyrophosphates form squalene. Third, squalene cyclizes and the product of this is converted to cholesterol. The building blocks that began this whole process were carbons from acetyl-CoA.
Example Question #4 : Sterols And Steroids
The first of three steps of cholesterol synthesis occurs in the cytoplasm. Where do the following two steps occur, respectively?
Cytoplasm
Cytoplasm; endoplasmic reticulum
Endoplasmic reticulum; Golgi apparatus
Endoplasmic reticulum
Endoplasmic reticulum; cytoplasm
Endoplasmic reticulum
The fist step of cholesterol synthesis is the synthesis of isopentenyl pyrophosphate from acetyl-CoA molecules, and this occurs in the cytoplasm. The second step of cholesterol synthesis is six isopentenyl pyrophosphate molecules converging to form squalene. This occurs in the endoplasmic reticulum. The third step of cholesterol synthesis is the cyclization of squalene and the final conversion of the molecule to cholesterol. This occurs in the endoplasmic reticulum.
Example Question #5 : Sterols And Steroids
Which step in cholesterol synthesis is the committed step?
Condensation of two farnesyl pyrophosphates by squalene synthase
Cyclization of squalene
Synthesis of mevalonate by HMG-CoA reductase
Isomerization of isopentenyl pyrophosphate to dimethyallyl pyrophosphate
Synthesis of squalene from isopentenyl pyrophosphate units
Synthesis of mevalonate by HMG-CoA reductase
Once acetyl-CoA molecules have been converted to 3-hydroxy-3-methylglutary-CoA (HMG-CoA), reduction to mevalonate occurs. This synthesis is an irreversible step in the pathway to create cholesterol, and therefore it is the committed step in cholesterol synthesis.
Example Question #21 : Lipid Structures And Functions
Lysosomal storage diseases occur when mutations cause defects in which of the following?
Formation of N-acetylgalactosamine derivatives
Lysosome transformation
Sphingolipid biosynthesis enzymes
Sphingolipid degradation enzymes
Lysosome formation
Sphingolipid degradation enzymes
Lysosomal storage diseases occur when mutations cause defects in sphingolipid degradation enzymes. Simply put, the key word is "degradation," which indicates the presence of a disease. No other answer choice has a key word that indicates the presence of a disease.
Example Question #2 : Sphingolipids
Which of the following is the smallest sphingolipid in terms of molecular mass?
Sphingomyelin
Ceramide
Ganglioside
Cerebroside
Sphingomyelin
All four of these sphingolipids differ only in the functional groups attached to the sphingosine. Ceramide has a fatty acid group; cerebroside has a monosaccharide group; ganglioside has a polysaccharide group; sphingomyelin has a phosphatidylcholine or phosphoethanolamine group. In terms of molecular mass, phosphatyidylcholine or phosphoethanolamine are the smallest as well as the least massive functional group, making sphingomyelin the sphingolipid with the smallest molecular mass.
Example Question #24 : Lipid Classifications
Ceramide is a precursor to which of the following?
Sphingolipids only
Glycoshingolipids only
Sphingomyelin only
Sphingomyelin and glycosphingolipids
Sphingosine
Sphingomyelin and glycosphingolipids
Ceramide is formed by sphingosine. Sphingosine is formed by a long chain of sphingolipids. Both sphingomyelin and glycosphingolipids are formed from ceramide.
Example Question #21 : Lipid Structures And Functions
Which of the following is amphipathic, polar, and are formed by long-chain sphingolipids?
Ceramide
Glucosamine
Palmitoyl-CoA
Sphingomyelin
Sphingosine
Sphingosine
Glucosamine contributes to the structure of glycosylphosphatidylinositol (GPI). Ceramide is the precursor to sphingomyelin, sphingosine is hydrolyzed to form ceramide.
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