Biochemistry : Lipid Structures and Functions

Study concepts, example questions & explanations for Biochemistry

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Example Questions

Example Question #21 : Lipid Structures And Functions

A steroid molecule consists of how many fused carbon rings?

Possible Answers:

2

4

5

6

3

Correct answer:

4

Explanation:

Steroids are derivatives of the molecule cyclopentanoperhydrophenanthrene which is composed of 4 fused carbon rings. There are three hexane rings and one pentane ring in the structure of steroids.

Example Question #1 : Sterols And Steroids

Cholesterol has a structure most similar to which of these?

Possible Answers:

Steroid

Glycolipid

Free fatty acid

Carbohydrate

Phospholipid

Correct answer:

Steroid

Explanation:

Although it is one of the three main types of membrane lipids (along with phospholipids and glycolipids) cholesterol's structure is quite different.  It is a steroid, and so it is made from four linked hydrocarbon rings, including three six-membered rings and one five-membered ring.

Example Question #2 : Sterols And Steroids

Which of the following is not made from cholesterol?

Possible Answers:

Testosterone

Estrodiol

Cortisol

Insulin

Progesterone

Correct answer:

Insulin

Explanation:

Cholesterol is a very important molecule for a number of reasons. One function of cholesterol is to regulate membrane fluidity in the plasma membrane. Another very important role that cholesterol plays is as the precursor to a number of steroid hormones including cortisol, testosterone, estradiol, and progesterone. Insulin, however, is a peptide hormone made in the pancreas.

Example Question #21 : Lipid Classifications

All of the carbons in cholesterol are derived from carbons in what molecule?

Possible Answers:

Glycerol

Mevalonate

Acetoacetate

Glucose

Acetyl-CoA

Correct answer:

Acetyl-CoA

Explanation:

Cholesterol is a molecule with 27 carbon atoms. In order to synthesize this steroid, a three step process must be completed. First, isopentenyl pyrophosphate is synthesized. Second, six isopentenyl pyrophosphates form squalene. Third, squalene cyclizes and the product of this is converted to cholesterol. The building blocks that began this whole process were carbons from acetyl-CoA.

Example Question #4 : Sterols And Steroids

The first of three steps of cholesterol synthesis occurs in the cytoplasm. Where do the following two steps occur, respectively?

Possible Answers:

Endoplasmic reticulum

Endoplasmic reticulum; Golgi apparatus

Endoplasmic reticulum; cytoplasm

Cytoplasm

Cytoplasm; endoplasmic reticulum

Correct answer:

Endoplasmic reticulum

Explanation:

The fist step of cholesterol synthesis is the synthesis of isopentenyl pyrophosphate from acetyl-CoA molecules, and this occurs in the cytoplasm. The second step of cholesterol synthesis is six isopentenyl pyrophosphate molecules converging to form squalene. This occurs in the endoplasmic reticulum. The third step of cholesterol synthesis is the cyclization of squalene and the final conversion of the molecule to cholesterol. This occurs in the endoplasmic reticulum.

Example Question #5 : Sterols And Steroids

Which step in cholesterol synthesis is the committed step?

Possible Answers:

Condensation of two farnesyl pyrophosphates by squalene synthase 

Synthesis of mevalonate by HMG-CoA reductase

Cyclization of squalene

Isomerization of isopentenyl pyrophosphate to dimethyallyl pyrophosphate

Synthesis of squalene from isopentenyl pyrophosphate units

Correct answer:

Synthesis of mevalonate by HMG-CoA reductase

Explanation:

Once acetyl-CoA molecules have been converted to 3-hydroxy-3-methylglutary-CoA (HMG-CoA), reduction to mevalonate occurs. This synthesis is an irreversible step in the pathway to create cholesterol, and therefore it is the committed step in cholesterol synthesis.

Example Question #1 : Sphingolipids

Lysosomal storage diseases occur when mutations cause defects in which of the following?

Possible Answers:

Formation of N-acetylgalactosamine derivatives

Lysosome formation

Sphingolipid degradation enzymes

Sphingolipid biosynthesis enzymes

Lysosome transformation

Correct answer:

Sphingolipid degradation enzymes

Explanation:

Lysosomal storage diseases occur when mutations cause defects in sphingolipid degradation enzymes. Simply put, the key word is "degradation," which indicates the presence of a disease. No other answer choice has a key word that indicates the presence of a disease.

Example Question #22 : Lipid Classifications

Which of the following is the smallest sphingolipid in terms of molecular mass? 

Possible Answers:

Ceramide

Ganglioside

Cerebroside

Sphingomyelin

Correct answer:

Sphingomyelin

Explanation:

All four of these sphingolipids differ only in the functional groups attached to the sphingosine. Ceramide has a fatty acid group; cerebroside has a monosaccharide group; ganglioside has a polysaccharide group; sphingomyelin has a phosphatidylcholine or phosphoethanolamine group. In terms of molecular mass, phosphatyidylcholine or phosphoethanolamine are the smallest as well as the least massive functional group, making sphingomyelin the sphingolipid with the smallest molecular mass. 

Example Question #23 : Lipid Classifications

Ceramide is a precursor to which of the following?

Possible Answers:

Sphingomyelin and glycosphingolipids

Sphingosine

Sphingolipids only

Sphingomyelin only

Glycoshingolipids only

Correct answer:

Sphingomyelin and glycosphingolipids

Explanation:

Ceramide is formed by sphingosine. Sphingosine is formed by a long chain of sphingolipids. Both sphingomyelin and glycosphingolipids are formed from ceramide.

Example Question #1 : Sphingolipids

Which of the following is amphipathic, polar, and are formed by long-chain sphingolipids?

Possible Answers:

Glucosamine

Ceramide

Sphingomyelin

Sphingosine

Palmitoyl-CoA

Correct answer:

Sphingosine

Explanation:

Glucosamine contributes to the structure of glycosylphosphatidylinositol (GPI). Ceramide is the precursor to sphingomyelin, sphingosine is hydrolyzed to form ceramide.

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