AP Biology : Endocrine System

Study concepts, example questions & explanations for AP Biology

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Example Questions

Example Question #21 : Understanding Hormones

Most hormone regulatory signaling is based on negative feedback control mechanisms. What hormone operates through a positive feedback mechanism?

Possible Answers:

Oxytocin 

Calcitonin

Insulin

Vasopressin

Correct answer:

Oxytocin 

Explanation:

The oxytocin pathway is an example of a positive feedback mechanism. Unlike negative feedback, which counteracts a stimulation, positive feedback reinforces a stimulus, leading to an even greater response.

One key function of oxytocin in mammals is to regulate the release of milk during nursing. In this case, the initial stimulus in the oxytocin pathway is an infant suckling, which stimulates sensory nerve cells in the nipples. The signal is received in the hypothalamus, which signals the posterior pituitary to secrete more oxytocin. Additional oxytocin is released into the bloodstream, signaling the mammary glands to secrete milk and perpetuating the stimulation of the hypothalamus. Oxytocin participates in a similar positive feedback loop when it stimulates uterine contractions during birth.

Vasopressin (antidiuretic hormone) is moderated by a negative feedback loop based on blood pressure. Based on pressure sensors in the body, vasopressin will be released or inhibited. Insulin and glucagon work in a negative feedback loop via sensors in the pancreas to moderate blood glucose levels. Calcitonin and parathyroid hormone work in a negative feedback loop to moderate blood calcium.

Example Question #31 : Endocrine System

Which of the following is a target of follicle-stimulating hormone (FSH)?

Possible Answers:

Mammary glands

Anterior pituitary

Adrenal gland

Testes

Correct answer:

Testes

Explanation:

Follicle-stimulating hormone (FSH) is a tropic hormone produced in the anterior pituitary. Its primary functions are to regulate development, growth, pubertal maturation, and reproductive processes of the human body.  

In males, follicle-stimulating hormone acts on the testes to promote spermatogenesis. In females, follicle-stimulating hormone is an important modulator of the menstrual cycle.

Example Question #23 : Understanding Hormones

Which of the given elements is a component of thyroid hormone?

Possible Answers:

Potassium

Zinc

Iodine

Copper

Correct answer:

Iodine

Explanation:

There are two types of thyroid hormone: T3 and T4. Both hormones are derived from the amino acid tyrosine, and are created by the addition of iodine atoms to the amino acid structure. The full name of T3 is triiodothyronine (three iodine atoms) and the full name of T4 is tetraiodothyronine (four iodine atoms). Because iodine is specific to the production of thyroid hormone, radioactive iodine is used to gather images of the thyroid gland.  

If iodine levels are low, the thyroid cannot produce sufficient thyroid hormone. The result is hypothyroidism. Symptoms of hypothyroidism include weight gain, lethargy, and intolerance to cold. In extreme cases, the thyroid will enlarge in an attempt to produce more hormone, resulting in a goiter.

Example Question #1476 : Ap Biology

Which of the following statements is not true of melatonin?

Possible Answers:

Melatonin is produced in the pineal gland

Melatonin is structurally similar to corticosteroids

Melatonin's main function is to regulate functions related to light and changes in day length

Melatonin affects skin pigmentation

Correct answer:

Melatonin is structurally similar to corticosteroids

Explanation:

Melatonin is a modified amino acid that is secreted by the pineal gland. The pineal gland contains light-sensitive cells and has nervous connections to the eyes that affect its secretory activity. As a result, melatonin regulates functions related to light, circadian rhythm, and seasonal alterations based on the amount of daylight.

Melatonin is secreted at night, and the amount released depends on the length of the night. In winter, for example, more melatonin is released. Melatonin is believed to target a group of neurons in the hypothalamus called the suprachiasmatic nucleus (SCN), which functions as a biological clock. 

Melatonin also affects skin pigmentation in many vertebrates.

Since melatonin is a modified amino acid, its structure is very different from that of corticosteroids, which are synthesized from the lipid cholesterol. Melatonin has two rings (similar to tryptophan), a modified ether group (from the carboxylic acid of the amino acid), and an amide group (from the amine group of the amino acid). Corticosteroids have four rings and multiple hydroxyl and ketone groups.

Example Question #24 : Understanding Hormones

Which of the following is not true of hormones?

Possible Answers:

Hormones affect only one specific tissue at a time.

Hormones are relatively slow acting compared to neurotransmitters.

Hormones are released directly into body fluids and tissues.

All of these are true of hormones.

Hormones affect a wider range of the body compared to neurotransmitters.

Correct answer:

Hormones affect only one specific tissue at a time.

Explanation:

Hormones are generally slow acting, spread throughout the body by the blood, and can affect a variety of tissues at once. Neurotransmitters on the other hand, are quick acting, localized, and affect only a specific cell. We would not expect hormones to affect only one cell or tissue at a time, as their wide distribution allows them to have multiple target areas.

Example Question #25 : Understanding Hormones

Parathyroid hormone (PTH) is a peptide hormone responsible for increasing the concentration of calcium in the blood. This is accomplished by stimulating the activity of osteoclasts and removing calcium from the bones.

If a person has low blood calcium levels, what would you expect the level of PTH to be in the body?

Possible Answers:

Parathyroid hormone would be higher than normal in the blood.

Normal levels of parathyroid hormone would be seen as it works to restore normal calcium levels.

Parathyroid levels will fluctuate until normal calcium levels are restored.

Normal levels of parathyroid hormone would be seen as a different hormone works to restore normal calcium levels.

Parathyroid hormone would be lower than normal in the blood.

Correct answer:

Parathyroid hormone would be higher than normal in the blood.

Explanation:

A critical concept to understand about hormones in the body is negative feedback. Remember that hormones are not causing the body's condition, but rather, are responding to the body's condition. As a result, parathyroid hormone would be higher than normal in order to increase the concentration of calcium currently in the blood, correcting the existing deficiency.

Example Question #26 : Understanding Hormones

__________ is the hormone responsible for milk production in female mammals. It is released by the __________.

Possible Answers:

Prolactin . . . anterior pituitary

Oxytocin . . . anterior pituitary

Prolactin . . . posterior pituitary

Prolactin . . . mammary glands

Oxytocin . . . posterior pituitary

Correct answer:

Prolactin . . . anterior pituitary

Explanation:

Prolactin is responsible for the production of milk, while oxytocin is responsible for the ejection of milk. The question asks for the hormone that causes production, so the answer is prolactin. Prolactin is released from the anterior pituitary.

Oxytocin is released from the posterior pituitary and the mammary glands are responsible for releasing milk.

Example Question #1480 : Ap Biology

Which of the following describes paracrine signaling? 

Possible Answers:

Secretion of molecules that diffuse locally and trigger a response in the same cells that secreted them

Secretion of molecules that diffuse locally and trigger a response on neighboring cells

Secretion of neurotransmitters that diffuse across synapses and trigger a response in cells of target tissues (neurons, muscles, and glands)

Secretion of molecules that diffuse into the bloodstream and trigger a response in target cells anywhere in the body

Correct answer:

Secretion of molecules that diffuse locally and trigger a response on neighboring cells

Explanation:

Hormones and other signaling molecules generate physiological responses by binding to specific receptor proteins in or on target cells. Only cells that have receptors for the secreted molecule (hormone, neurotransmitter, neurohormone, etc.) are target cells; other cells are nonresponsive. 

There are five different classifications for molecular signaling. These are as follow:  

Endocrine signaling:  Secreted molecules diffuse into the bloodstream and trigger responses in target cells throughout the body.

Paracrine signaling:  Signaling molecules diffuse locally and trigger a response in neighboring cells.

Autocrine signaling:  Secretion of molecules that diffuse locally and trigger a response on the same cells that secreted them.

Synaptic signaling:  Secretion of neurotransmitters that diffuse across synapses and trigger a response in cells or target tissues (neurons, glands, and muscles).

Neuroendocrine signaling:  Secretion of hormones from neuronal cells that diffuse into the bloodstream and trigger a response on cells throughout the body.

Example Question #32 : Endocrine System

Which of the following is not true about water-soluble hormones?

Possible Answers:

Binding to its receptor can initiate a signal transduction cascade

Tyrosine-derivative hormones are water-soluble

Their receptors are found on the cell membrane

They act as local regulators

Correct answer:

They act as local regulators

Explanation:

Water-soluble hormones can be either polypeptides (proteins) or tyrosine-derivatives. The binding of a water-soluble hormone to a receptor occurs on the cell membrane, and receptor binding triggers a physiological response through a signal transduction cascade. Peptide hormones include insulin, growth hormone, oxytocin, adrenocorticotropic hormone, and many more. Tyrosine-derivative hormones include epinephrine and the thyroid hormones (T3 and T4).

Water-soluble hormones, like most hormones, are secreted into the bloodstream and carried throughout the body. As such, they are capable of eliciting responses in non-local regions of the body, and would not be classified as local regulators.

Example Question #511 : Systems Physiology

Vasopressin is released when sensory neurons in the hypothalamus detect a rise in the osmolarity of the blood. When secreted, this hormone causes changes in water reabsorption by the kidneys. This is an example of what type of signaling?

Possible Answers:

Neuroendocrine signaling

Synaptic signaling

Paracrine signaling

Autocrine signaling

Correct answer:

Neuroendocrine signaling

Explanation:

Neuroendocrine signaling describes the process when specialized neural sensors, usually in the brain, detect changes in the body. These sensors stimulate the release of a hormone to help correct deviations. The hormone can travel via the bloodstream to affect distant tissues.

In this example, sensor neurons in the hypothalamus trigger the release of the hormone vasopressin to affect the kidney.

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