Heart Failure And Cardiomyopathies

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USMLE Step 2 CK › Heart Failure And Cardiomyopathies

Questions 1 - 10
1

A 75-year-old man with HFrEF (EF 20%) presents with dyspnea, fatigue, and edema. Exam shows JVD, rales, S3. BP 118/70. Labs: BNP 2300 pg/mL; troponin negative. CXR shows pulmonary edema. Echo shows EF 20% with left bundle branch block on ECG and QRS 170 ms. After stabilization on guideline-directed therapy, which of the following is the most appropriate next step in management?

Immediate coronary angiography despite no ischemic symptoms

Cardiac resynchronization therapy evaluation

Start verapamil for conduction system support

Stop beta-blocker permanently due to low EF

Treat with antibiotics for presumed myocarditis

Explanation

This question tests the ability to manage heart failure and cardiomyopathies by applying clinical guidelines and evidence-based practices. Heart failure management requires understanding the type of failure (systolic vs diastolic) and selecting appropriate therapies. In the given scenario, the patient’s echocardiogram and symptoms suggest heart failure with reduced ejection fraction (HFrEF) with left bundle branch block (LBBB) and wide QRS complex, which guides the management approach. The correct answer is Choice A because it aligns with ACC/AHA guidelines for treating HFrEF patients with EF ≤35%, NYHA class II-IV symptoms, LBBB, and QRS ≥150 ms, ensuring best patient outcomes through cardiac resynchronization therapy (CRT) evaluation. Choice C is incorrect due to the common misconception that beta-blockers should be avoided in low EF, often seen when students overlook that beta-blockers are a cornerstone of guideline-directed medical therapy (GDMT) for HFrEF to improve survival and symptoms. Teaching strategies include reinforcing the differences between heart failure types, emphasizing the importance of guideline adherence, and practicing the application of evidence-based management in clinical scenarios.

2

A 62-year-old man with HFrEF (EF 28%) presents with dyspnea, fatigue, and edema. Exam shows JVD, rales, S3. BP 122/70. Labs: BNP 1450 pg/mL; troponin negative. CXR shows pulmonary congestion. After diuresis, he asks how to monitor himself at home to detect early fluid retention. What lifestyle modification should be recommended to this patient?

Daily morning weights and call for rapid gain

Avoid weighing to reduce anxiety

Stop all medications if urine output increases

Increase sodium intake before exercise

Drink extra fluids when legs swell

Explanation

This question tests the ability to manage heart failure and cardiomyopathies by applying clinical guidelines and evidence-based practices. Heart failure management requires understanding the type of failure (systolic vs diastolic) and selecting appropriate therapies. In the given scenario, the patient’s echocardiogram and symptoms suggest decompensated HFrEF amenable to self-monitoring, which guides the management approach. The correct answer is A because it aligns with ACC/AHA guidelines for patient education on weight monitoring, ensuring best patient outcomes. Choice B is incorrect due to potential discouragement of adherence, often seen when students underestimate the value of simple monitoring tools. Teaching strategies include reinforcing the differences between heart failure types, emphasizing the importance of guideline adherence, and practicing the application of evidence-based management in clinical scenarios.

3

A 61-year-old man with HFrEF (EF 22%) presents with acute dyspnea, orthopnea, and leg edema. Exam shows JVD, rales, S3. BP 158/90. Labs: BNP 1900 pg/mL; troponin negative. CXR shows pulmonary edema. He receives IV furosemide but has minimal urine output after 2 hours. Which of the following is the most appropriate next step in management?

Start verapamil to improve diastolic filling

Begin high-dose beta-blocker titration immediately

Stop diuretics and give IV fluids for renal perfusion

Switch to oral diuretics and discharge

Add a thiazide-type diuretic for sequential nephron blockade

Explanation

This question tests the ability to manage heart failure and cardiomyopathies by applying clinical guidelines and evidence-based practices. Heart failure management requires understanding the type of failure (systolic vs diastolic) and selecting appropriate therapies. In the given scenario, the patient’s echocardiogram and symptoms suggest diuretic-resistant decompensated HFrEF, which guides the management approach. The correct answer is A because it aligns with ACC/AHA guidelines for sequential nephron blockade in refractory edema, ensuring best patient outcomes. Choice B is incorrect due to the risk of worsening congestion, often seen when students overprioritize renal protection without addressing volume status. Teaching strategies include reinforcing the differences between heart failure types, emphasizing the importance of guideline adherence, and practicing the application of evidence-based management in clinical scenarios.

4

A 71-year-old woman with HFrEF (EF 30%) presents with dyspnea, orthopnea, fatigue, and edema. Exam shows JVD, rales, S3. BP 116/68. Labs: BNP 1900 pg/mL; troponin negative. CXR shows pulmonary edema. She is placed on IV diuretics. Which of the following lab abnormalities is most important to monitor closely during diuresis?

Serum uric acid level only

Serum amylase level

Serum vitamin B12 level

Serum bilirubin level

Serum potassium level

Explanation

This question tests the ability to manage heart failure and cardiomyopathies by applying clinical guidelines and evidence-based practices. Heart failure management requires understanding the type of failure (systolic vs diastolic) and selecting appropriate therapies. In the given scenario, the patient’s echocardiogram and symptoms suggest decompensated HFrEF requiring diuresis monitoring, which guides the management approach. The correct answer is A because it aligns with ACC/AHA guidelines for preventing hypokalemia during diuresis, ensuring best patient outcomes. Choice B is incorrect due to irrelevance to diuresis complications, often seen when students monitor unrelated labs. Teaching strategies include reinforcing the differences between heart failure types, emphasizing the importance of guideline adherence, and practicing the application of evidence-based management in clinical scenarios.

5

A 62-year-old man with HFrEF (EF 28%) presents with dyspnea, orthopnea, and edema. Exam: JVD, rales, S3. BP 128/74. Labs: BNP 1600 pg/mL; troponin negative. CXR shows pulmonary edema. He is on furosemide and carvedilol but not on an SGLT2 inhibitor. After stabilization, which medication addition is most appropriate to reduce heart failure hospitalization risk?

Add verapamil

Add ibuprofen

Add short-acting nifedipine

Add dobutamine as chronic outpatient infusion

Add dapagliflozin

Explanation

This question tests the ability to manage heart failure and cardiomyopathies by applying clinical guidelines and evidence-based practices. Heart failure management requires understanding the type of failure (systolic vs diastolic) and selecting appropriate therapies. In the given scenario, the patient’s echocardiogram and symptoms suggest stabilized decompensated HFrEF without SGLT2i, which guides the management approach. The correct answer is A because it aligns with ACC/AHA guidelines for adding SGLT2 inhibitors to reduce hospitalizations in HFrEF, ensuring best patient outcomes. Choice B is incorrect due to contraindication in systolic HF, often seen when students select therapies for diastolic HF. Teaching strategies include reinforcing the differences between heart failure types, emphasizing the importance of guideline adherence, and practicing the application of evidence-based management in clinical scenarios.

6

A 60-year-old man with HFrEF (EF 33%) presents with dyspnea and edema. Exam shows JVD, rales, S3. BP 136/80. Labs: BNP 1300 pg/mL; troponin negative. CXR shows pulmonary congestion. He reports taking an over-the-counter “cold medicine” for 5 days. Which medication is most likely contributing to his decompensation?

Acetaminophen

Guaifenesin

Saline nasal spray

Pseudoephedrine

Loratadine

Explanation

This question tests the ability to manage heart failure and cardiomyopathies by applying clinical guidelines and evidence-based practices. Heart failure management requires understanding the type of failure (systolic vs diastolic) and selecting appropriate therapies. In the given scenario, the patient’s echocardiogram and symptoms suggest decompensated HFrEF from OTC medication, which guides the management approach. The correct answer is A because it aligns with ACC/AHA guidelines avoiding sympathomimetics in HF, ensuring best patient outcomes. Choice B is incorrect due to lack of association with decompensation, often seen when students fail to identify vasoconstrictor effects. Teaching strategies include reinforcing the differences between heart failure types, emphasizing the importance of guideline adherence, and practicing the application of evidence-based management in clinical scenarios.

7

A 69-year-old woman with HFrEF (EF 32%) presents with dyspnea, fatigue, and edema. Exam shows JVD, rales, S3. BP 134/78. Labs: BNP 1700 pg/mL; troponin negative. CXR shows pulmonary edema. She has a new fever and productive cough; WBC 15,000/µL. Which of the following is the most appropriate next step in management?

Treat suspected pneumonia while giving IV diuretics

Stop diuretics until antibiotics are completed

Start high-dose beta-blocker escalation immediately

Give IV fluids to treat fever-related dehydration

Ignore infection because BNP is elevated

Explanation

This question tests the ability to manage heart failure and cardiomyopathies by applying clinical guidelines and evidence-based practices. Heart failure management requires understanding the type of failure (systolic vs diastolic) and selecting appropriate therapies. In the given scenario, the patient’s echocardiogram and symptoms suggest decompensated HFrEF with infection, which guides the management approach. The correct answer is A because it aligns with ACC/AHA guidelines for treating precipitants like infection alongside HF therapy, ensuring best patient outcomes. Choice B is incorrect due to overlooking infection, often seen when students attribute all symptoms to HF alone. Teaching strategies include reinforcing the differences between heart failure types, emphasizing the importance of guideline adherence, and practicing the application of evidence-based management in clinical scenarios.

8

A 57-year-old man with known HFrEF (EF 35%) presents with acute dyspnea, orthopnea, and edema. Exam: JVD, rales, S3. BP 164/96. Labs: BNP 1600 pg/mL; troponin negative. CXR shows pulmonary edema. He is started on IV loop diuretics. Which additional therapy is most appropriate to rapidly improve symptoms given his elevated blood pressure?

Begin high-dose digoxin as first-line therapy

Add intravenous nitrates for preload and afterload reduction

Stop diuretics and observe overnight only

Give IV fluids to maintain renal perfusion

Start verapamil to slow heart rate

Explanation

This question tests the ability to manage heart failure and cardiomyopathies by applying clinical guidelines and evidence-based practices. Heart failure management requires understanding the type of failure (systolic vs diastolic) and selecting appropriate therapies. In the given scenario, the patient’s echocardiogram and symptoms suggest hypertensive decompensated HFrEF, which guides the management approach. The correct answer is A because it aligns with ACC/AHA guidelines for vasodilators in hypertensive acute HF, ensuring best patient outcomes. Choice B is incorrect due to contraindication in systolic HF, often seen when students confuse rate control with afterload reduction. Teaching strategies include reinforcing the differences between heart failure types, emphasizing the importance of guideline adherence, and practicing the application of evidence-based management in clinical scenarios.

9

A 64-year-old woman with HFrEF (EF 30%) presents with dyspnea, fatigue, and edema. Exam shows JVD, rales, and S3. BP 126/74. Labs: BNP 1550 pg/mL; troponin negative; potassium 5.8 mEq/L; creatinine 2.3 mg/dL (baseline 1.8). CXR shows pulmonary congestion. Current meds include lisinopril, carvedilol, spironolactone, and furosemide. Which medication should be discontinued in light of her symptoms and labs?

Carvedilol

Furosemide

Spironolactone

Lisinopril

All heart failure medications permanently

Explanation

This question tests the ability to manage heart failure and cardiomyopathies by applying clinical guidelines and evidence-based practices. Heart failure management requires understanding the type of failure (systolic vs diastolic) and selecting appropriate therapies. In the given scenario, the patient’s echocardiogram and symptoms suggest decompensated HFrEF with hyperkalemia, which guides the management approach. The correct answer is A because it aligns with ACC/AHA guidelines for holding MRAs in hyperkalemia, ensuring best patient outcomes. Choice E is incorrect due to overgeneralization, often seen when students discontinue all therapies without identifying the culprit. Teaching strategies include reinforcing the differences between heart failure types, emphasizing the importance of guideline adherence, and practicing the application of evidence-based management in clinical scenarios.

10

A 60-year-old man with HFrEF (EF 25%) presents with dyspnea, orthopnea, fatigue, and edema. Exam: JVD, rales, S3. BP 146/88. Labs: BNP 1800 pg/mL; troponin negative. CXR shows pulmonary edema. Echo shows EF 25%. He improves after IV diuresis. Which of the following is the most appropriate next step in management before discharge regarding vaccination?

Recommend influenza and pneumococcal vaccination if not up to date

Delay all vaccines until EF normalizes

Vaccines are contraindicated with elevated BNP

Avoid vaccines due to risk of fluid overload

Recommend live vaccines only for heart failure patients

Explanation

This question tests the ability to manage heart failure and cardiomyopathies by applying clinical guidelines and evidence-based practices. Heart failure management requires understanding the type of failure (systolic vs diastolic) and selecting appropriate therapies. In the given scenario, the patient’s echocardiogram and symptoms suggest stabilized decompensated HFrEF, which guides the management approach. The correct answer is A because it aligns with ACC/AHA guidelines for vaccinations to prevent infections in HF, ensuring best patient outcomes. Choice B is incorrect due to misguided risk assessment, often seen when students invent contraindications without evidence. Teaching strategies include reinforcing the differences between heart failure types, emphasizing the importance of guideline adherence, and practicing the application of evidence-based management in clinical scenarios.

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