USMLE Step 1 Question of the Day
Test your knowledge with a hand-picked multiple-choice question.
A 45-year-old man with major depressive disorder and tobacco use disorder started bupropion SR 150 mg twice daily 3 weeks ago. He reports improved concentration and decreased cigarette cravings without sexual side effects. Past medical history includes hypertension and obesity; he denies seizures, eating disorders, or alcohol misuse. Examination is normal. Labs: fasting glucose 108 mg/dL, lipid panel borderline, TSH normal, and creatinine 0.9 mg/dL. He notes mild insomnia and dry mouth. EKG is normal. He asks about how this antidepressant works, given the lack of sexual dysfunction. Weight is unchanged, and blood pressure is well controlled on lisinopril. He does not drink caffeine late in the day.
This medication's therapeutic effect is mediated through which mechanism?