Electrical Signaling in Neurons (4C) Practice Test
•15 QuestionsIn a focused experiment on action potential propagation, a single myelinated motor neuron is stimulated at the axon hillock. Resting membrane potential is $V_m=-70\ \text{mV}$ and threshold is $-55\ \text{mV}$. Voltage-gated Na$^+$ channels open rapidly when threshold is reached, and voltage-gated K$^+$ channels open with a delay to repolarize the membrane. The axon is partially demyelinated over a 2-mm segment, increasing membrane capacitance in that segment from $C_m=1.0\ \mu\text{F}/\text{cm}^2$ to $2.5\ \mu\text{F}/\text{cm}^2$ while leaving ion channel densities unchanged. Assume intracellular and extracellular ion concentrations remain constant during a single spike and that the neuron is otherwise healthy. Which outcome is most consistent with the effect of the demyelinated segment on action potential propagation along the axon?
In a focused experiment on action potential propagation, a single myelinated motor neuron is stimulated at the axon hillock. Resting membrane potential is $V_m=-70\ \text{mV}$ and threshold is $-55\ \text{mV}$. Voltage-gated Na$^+$ channels open rapidly when threshold is reached, and voltage-gated K$^+$ channels open with a delay to repolarize the membrane. The axon is partially demyelinated over a 2-mm segment, increasing membrane capacitance in that segment from $C_m=1.0\ \mu\text{F}/\text{cm}^2$ to $2.5\ \mu\text{F}/\text{cm}^2$ while leaving ion channel densities unchanged. Assume intracellular and extracellular ion concentrations remain constant during a single spike and that the neuron is otherwise healthy. Which outcome is most consistent with the effect of the demyelinated segment on action potential propagation along the axon?